Early neurosyphilis with serofast state

We report a rare case of confirmed early neurosyphilis with serofast state in HIV-negative patient, with uncontrolled type 2 diabetes mellitus. Syphilitic meningitis was diagnosed initially on serology and cerebrospinal fluid (CSF) analysis. The patient had persistently raised non-treponemal titres...

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Bibliographic Details
Published in:Emerging microbes & infections 2024-12, Vol.13 (1), p.2373305
Main Authors: Zayet, Souheil, Poloni, Samantha, Gendrin, Vincent, Chanal, Johan, Dupin, Nicolas, Klopfenstein, Timothée
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - therapeutic use
Antibodies
Antibodies, Bacterial - blood
Antibodies, Bacterial - cerebrospinal fluid
Asymptomatic
Blood
Cerebrospinal fluid
Diabetes
Diabetes Mellitus, Type 2 - complications
HIV
Hospitals
Human immunodeficiency virus
Humans
Infections
Leukocytes
Magnetic resonance imaging
Male
Medical laboratories
Meningitis
Middle Aged
Neurosyphilis
Neurosyphilis - complications
Neurosyphilis - diagnosis
Neurosyphilis - drug therapy
nontreponemal antibodies
Pathogens
Patients
Polymerase chain reaction
Proteins
Research Letter
serofast
Serology
Sexually transmitted diseases
STD
Syphilis
Treponema pallidum - immunology
Treponema pallidum - isolation & purification
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Description
Summary:We report a rare case of confirmed early neurosyphilis with serofast state in HIV-negative patient, with uncontrolled type 2 diabetes mellitus. Syphilitic meningitis was diagnosed initially on serology and cerebrospinal fluid (CSF) analysis. The patient had persistently raised non-treponemal titres on serum with negative CSF venereal disease research laboratory result, following treatment during 3 years of follow-up.
ISSN:2222-1751
2222-1751
DOI:10.1080/22221751.2024.2373305