The Acre Project: the epidemiology of malaria and arthropod-borne virus infections in a rural Amazonian population

The authors describe the baseline malaria prevalence and arbovirus seroprevalence among 467 subjects in an ongoing cohort study in rural Amazonia. Most subjects (72.2%) reported one or more previous episodes of malaria, and 15.6% had been hospitalized for malaria, but only 3.6% of individuals five y...

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Bibliographic Details
Published in:Cadernos de saúde pública 2006-06, Vol.22 (6), p.1325-1334
Main Authors: Silva-Nunes, Mônica da, Malafronte, Rosely dos Santos, Luz, Bruna de Almeida, Souza, Estéfano Alves de, Martins, Lívia Carício, Rodrigues, Sueli Guerreiro, Chiang, Jannifer Oliveira, Vasconcelos, Pedro Fernando da Costa, Muniz, Pascoal Torres, Ferreira, Marcelo Urbano
Format: Article
Language:English
Subjects:
Adolescent
Adult
Amazonian Ecosystem
Antibodies, Viral - blood
Arbovirus Infections
Arbovirus Infections - epidemiology
Arbovirus Infections - immunology
Arboviruses
Arboviruses - immunology
Brazil - epidemiology
Child
Child, Preschool
Cross Reactions
Dengue
Dengue Virus - immunology
Ecosystem
Endemic Diseases
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoglobulin G - blood
Infant
Malaria
Malaria - epidemiology
Malaria - immunology
Male
Middle Aged
Prevalence
PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Rural Population
Seroepidemiologic Studies
Sex Factors
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Summary:The authors describe the baseline malaria prevalence and arbovirus seroprevalence among 467 subjects in an ongoing cohort study in rural Amazonia. Most subjects (72.2%) reported one or more previous episodes of malaria, and 15.6% had been hospitalized for malaria, but only 3.6% of individuals five years or older had malaria parasites detected by microscopy (10 with Plasmodium vivax and 4 with P. falciparum). Antibodies to Alphavirus, Orthobunyavirus, and/or Flavivirus were detected by hemagglutination inhibition (HI) in 42.6% of subjects aged five years or older, with a higher seropositivity rate among males (49.2%) than females (36.2%). Since 98.9% of subjects had been immunized for yellow fever, the presence of cross-reactive antibodies to dengue and other Flaviviruses cannot be ruled out, but at least 12 subjects (3.3%) with IgM antibodies to dengue virus detected by ELISA had a putative recent exposure to this virus.
ISSN:0102-311X
1678-4464
0102-311X
1678-4464
DOI:10.1590/S0102-311X2006000600021