Higher Responsiveness for Women, High Transaminase Levels, and Fat Percentage to Pemafibrate Treatment for NAFLD

• Published in: Biomedicines 2022-11, Vol.10 (11), p.2806
• Main Authors: Iwadare, Takanobu, Kimura, Takefumi, Kunimoto, Hideo, Tanaka, Naoki, Wakabayashi, Shun-Ichi, Yamazaki, Tomoo, Okumura, Taiki, Kobayashi, Hiroyuki, Yamashita, Yuki, Sugiura, Ayumi, Joshita, Satoru, Umemura, Takeji
• Format: Article
• Language: English
• Subjects: Alanine transaminase; Aspartate aminotransferase; Body composition; Body fat; Body mass index; Body weight; Cholesterol; Fatty acids; Fatty liver; FDA approval; Hospitals; Hypertension; Hypertriglyceridemia; Lipids; Liver cancer; Liver diseases; Metabolism; Musculoskeletal system; non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; Patients; pemafibrate; Peroxisome proliferator-activated receptors; Physiological aspects; Sarcopenia; selective PPARα modulator; treatment prediction; Triglycerides; Womens health
• ISSN: 2227-9059; 2227-9059
• DOI: 10.3390/biomedicines10112806

Aim: Pemafibrate (PEM) is a novel selective peroxisome proliferator-activated receptor alpha modulator that is effective for hypertriglyceridemia accompanying non-alcoholic fatty liver disease (HTG-NAFLD). This study aimed to identify the predictors of PEM efficacy for HTG-NAFLD in clinical practice. Methods: We retrospectively enrolled 88 HTG-NAFLD patients treated with PEM for 6 months for the analysis of routine blood and body composition testing. A PEM response was defined as a decrease in serum alanine aminotransferase (ALT) of >30% compared with pre-treatment level. The clinical features related to PEM responsiveness were statistically tested between responders and non-responders. Results: All 88 patients completed the 6 month drug regimen without any adverse effects. PEM treatment significantly decreased liver enzymes, triglycerides, and total cholesterol levels, without any detectable impact on body weight or body composition. Comparisons of baseline clinical features revealed female and greater aspartate aminotransferase (AST), ALT, and fat mass % levels to be significantly associated with a PEM response. The optimal cut-off values to predict responders as determined by receiver operating characteristic analysis were AST 45 U/L, ALT 60 U/L, and fat mass 37%. Conclusions: Female HTG-NAFLD patients with higher transaminase and fat mass % levels may be preferentially indicated for PEM treatment. Additional large-scale prospective studies are warranted to verify our results.