Asymmetric synthesis of (7aS)-7a-methyl-4,5,7,7a-tetrahydro-1H-indene-2,6-dione and useful derivatives thereof

The enantioselective synthesis of the title compound, using Meyers' bicyclic lactam methodology, is described. This compound and a few of its derivatives are useful intermediates in natural product synthesis.

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2006-09, Vol.11 (9), p.707-713
Main Authors: Demin, Samuël, Van Haver, Dirk, De Clercq, Pierre J
Format: Article
Language:English
Subjects:
Asymmetric synthesis
Bridged Bicyclo Compounds - chemical synthesis
Bridged Bicyclo Compounds - chemistry
Chromatography
hydrindenones
Hydrogenation
Indenes - chemical synthesis
Indenes - chemistry
Ketones - chemical synthesis
Ketones - chemistry
Lactams - chemistry
Meyers' bicyclic lactam template
Stereoisomerism
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Description
Summary:The enantioselective synthesis of the title compound, using Meyers' bicyclic lactam methodology, is described. This compound and a few of its derivatives are useful intermediates in natural product synthesis.
ISSN:1420-3049
1420-3049
DOI:10.3390/11090707