Clinical features and predictors of atrial fibrillation in patients with light‐chain or transthyretin cardiac amyloidosis

Aims The study aimed to investigate the prevalence, phenotypic characteristics, and predictors of atrial fibrillation (AF) in patients presenting with cardiac amyloidosis (CA) of light‐chain (AL) or transthyretin (ATTR) type. Methods and results Clinical, biochemical, and echocardiographic data of p...

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Bibliographic Details
Published in:ESC Heart Failure 2022-06, Vol.9 (3), p.1740-1748
Main Authors: Papathanasiou, Maria, Jakstaite, Aiste‐Monika, Oubari, Sara, Siebermair, Johannes, Wakili, Reza, Hoffmann, Julia, Carpinteiro, Alexander, Hagenacker, Tim, Thimm, Andreas, Rischpler, Christoph, Kessler, Lukas, Rassaf, Tienush, Luedike, Peter
Format: Article
Language:English
Subjects:
Aged
Amyloidosis
Atrial Appendage
Atrial fibrillation
Atrial Fibrillation - diagnosis
Atrial Fibrillation - epidemiology
Atrial Fibrillation - etiology
Biomarkers
Biopsy
Brain Ischemia
Cardiac arrhythmia
Cardiomyopathy
Chronic obstructive pulmonary disease
Female
Heart failure
Humans
Immunoglobulin Light-chain Amyloidosis - complications
Immunoglobulin Light-chain Amyloidosis - diagnosis
Immunoglobulin Light-chain Amyloidosis - epidemiology
Light‐chain
Male
Original
Peptides
Prealbumin - genetics
Prospective Studies
Retrospective Studies
Scintigraphy
Stroke
Stroke Volume
Thromboembolism
Tomography
Transthyretin
Variables
Ventricular Function, Left
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Summary:Aims The study aimed to investigate the prevalence, phenotypic characteristics, and predictors of atrial fibrillation (AF) in patients presenting with cardiac amyloidosis (CA) of light‐chain (AL) or transthyretin (ATTR) type. Methods and results Clinical, biochemical, and echocardiographic data of patients presenting with CA between 2005 and 2020 were retrospectively collected. CA staging was based on established biomarker systems. Binomial logistic regression was run to analyse the effects of clinical variables on the likelihood of AF. The study included 133 patients [53% AL, 41% wild‐type (wt) ATTR‐CA, & 6% hereditary ATTR‐CA]. Mean age was 71 years, and 80% were male patients. AF was diagnosed in 64 (48%) patients (28% in AL‐CA, 80% in wtATTR, 13% in hATTR, P 
ISSN:2055-5822
2055-5822
DOI:10.1002/ehf2.13851