Neutrophil extracellular traps in adult diseases and neonatal bacterial infectious diseases: A review

Neutrophils, the most abundant type of white blood cells, are pivotal in fighting bacterial infections due to their immunological and anti-infection capabilities. In recent years, scientists have discovered a novel mechanism known as neutrophil extracellular traps, which are fibrous networks primari...

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Bibliographic Details
Published in:Heliyon 2024-01, Vol.10 (1), p.e23559-e23559, Article e23559
Main Authors: Li, Ziheng, Yuan, Tianming
Format: Article
Language:English
Subjects:
Necrotizing enterocolitis
Neonatal sepsis
Neutrophil
Neutrophil extracellular traps
Purulent meningitis
Review
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Summary:Neutrophils, the most abundant type of white blood cells, are pivotal in fighting bacterial infections due to their immunological and anti-infection capabilities. In recent years, scientists have discovered a novel mechanism known as neutrophil extracellular traps, which are fibrous networks primarily released by neutrophils that combat bacterial infections. There is a growing interest in studying NETs and their role in human infectious diseases, particularly in neonates susceptible to bacterial infections. NETs and their components have been found in various samples from neonatal-infected patients, providing a new route for early diagnosis of neonatal infectious diseases. This paper aims to summarize the studies on NETs in adult diseases and mainly discuss NETs in neonatal sepsis, necrotizing enterocolitis, and purulent meningitis, to provide scientific evidence for early monitoring, diagnosis, and treatment of neonatal infections.
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2023.e23559