Macular Telangiectasia Type 2: A Comprehensive Review

Macular telangiectasia Type 2 (MacTel) is a gradually progressive disease that affects the quality of life by impairing both distant and near vision. It had previously been considered a vascular condition, but recent evidence suggests a neurodegenerative etiology, with primary involvement of Muller...

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Bibliographic Details
Published in:Clinical ophthalmology (Auckland, N.Z.) N.Z.), 2022-10, Vol.16, p.3297-3309
Main Authors: Kedarisetti, Kiran Chandra, Narayanan, Raja, Stewart, Michael W, Gurram, Nikitha Reddy, Khanani, Arshad M
Format: Article
Language:English
Subjects:
Atrophy
Biosynthesis
Blood vessels
Cardiovascular disease
Ciliary neurotrophic factor
cntf
Development and progression
Diabetes
Diabetic retinopathy
Edema
Hyperplasia
Hypertension
mactel
macular telangiectasia type 2
Medical imaging
Mutation
Neurodegeneration
Photoreceptors
Retina
Review
review article
Telangiectasis
Twins
Vascular endothelial growth factor
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Summary:Macular telangiectasia Type 2 (MacTel) is a gradually progressive disease that affects the quality of life by impairing both distant and near vision. It had previously been considered a vascular condition, but recent evidence suggests a neurodegenerative etiology, with primary involvement of Muller cells. Retinal pigment epithelium (RPE) hyperplasia and subretinal neovascularization (SNV) are responsible for most of the vision loss in advanced cases. Neurotrophic factors in the non-proliferative phase and intravitreal anti-Vascular Endothelial growth factor (VEGF) in the proliferative phase have shown to retard the progression of the disease. This review will discuss the pathophysiology, clinical features, important diagnostic imaging studies and available treatment options for MacTel. Keywords: macular telangiectasia type 2, MacTel, CNTF, ciliary neurotrophic factor
ISSN:1177-5483
1177-5467
1177-5483
DOI:10.2147/OPTH.S373538