Peripheral Vγ9Vδ2 T Cells Are a Novel Reservoir of Latent HIV Infection

Eradication of HIV infection will require the identification of all cellular reservoirs that harbor latent infection. Despite low or lack of CD4 receptor expression on Vδ2 T cells, infection of these cells has previously been reported. We found that upregulation of the CD4 receptor may render primar...

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Bibliographic Details
Published in:PLoS pathogens 2015-10, Vol.11 (10), p.e1005201-e1005201
Main Authors: Soriano-Sarabia, Natalia, Archin, Nancie M, Bateson, Rosalie, Dahl, Noelle P, Crooks, Amanda M, Kuruc, JoAnn D, Garrido, Carolina, Margolis, David M
Format: Article
Language:English
Subjects:
CD4-Positive T-Lymphocytes - virology
Cell Separation
Flow Cytometry
HIV Infections - virology
HIV-1 - physiology
Humans
Receptors, Antigen, T-Cell, gamma-delta
T-Lymphocyte Subsets - virology
Virus Latency - physiology
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Summary:Eradication of HIV infection will require the identification of all cellular reservoirs that harbor latent infection. Despite low or lack of CD4 receptor expression on Vδ2 T cells, infection of these cells has previously been reported. We found that upregulation of the CD4 receptor may render primary Vδ2 cells target for HIV infection in vitro and we propose that HIV-induced immune activation may allow infection of γδ T cells in vivo. We assessed the presence of latent HIV infection by measurements of DNA and outgrowth assays within Vδ2 cells in 18 aviremic patients on long-standing antiretroviral therapy. In 14 patients we recovered latent but replication-competent HIV from highly purified Vδ2 cells demonstrating that peripheral Vδ2 T cells are a previously unrecognized reservoir in which latent HIV infection is unexpectedly frequent.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1005201