High serum triglyceride levels in the early first trimester of pregnancy are associated with gestational diabetes mellitus: A prospective cohort study

Aims/Introduction Pregnant women with gestational diabetes mellitus (GDM) have been reported to have higher serum triglyceride (TG) levels during the entire gestational period. However, whether TGs contribute to the incidence of GDM remains unclear. This study aimed to evaluate whether higher serum...

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Bibliographic Details
Published in:Journal of diabetes investigation 2020-11, Vol.11 (6), p.1635-1642
Main Authors: Zhu, Haiyan, He, Dian, Liang, Ning, Lai, Ailuan, Zeng, Jingbo, Yu, Huanling
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
Body Mass Index
Case-Control Studies
China - epidemiology
Cohort analysis
Diabetes mellitus
Diabetes, Gestational - blood
Diabetes, Gestational - epidemiology
Diabetes, Gestational - etiology
Diabetes, Gestational - pathology
Female
Follow-Up Studies
Gestational age
Gestational diabetes
Gestational diabetes mellitus
Glucose
Humans
Hypertension
Hypertriglyceridemia - complications
Lipids
Menstruation
Metabolism
Original
Overweight
Pregnancy
Pregnancy Trimester, First
Prognosis
Prospective Studies
Questionnaires
Regression analysis
Risk Factors
Triglyceride
Triglycerides - blood
Variance analysis
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Summary:Aims/Introduction Pregnant women with gestational diabetes mellitus (GDM) have been reported to have higher serum triglyceride (TG) levels during the entire gestational period. However, whether TGs contribute to the incidence of GDM remains unclear. This study aimed to evaluate whether higher serum TG level during early first trimester is associated with GDM. Materials and Methods A prospective single‐center cohort study was carried out among pregnant women (n = 2,949) who received regular antenatal care in Fu Xing Hospital, Capital Medical University, Beijing, China. GDM was diagnosed between 24 and 28 gestational weeks. Serum TG levels were measured during gestational weeks 6–8 (TG0) and 16–18 (TG1). TG elevation was the difference between TG1 and TG0. Results In total, 581 pregnant women developed GDM. A 13.1, 18.5 and 28.8% incidence of GDM was observed in women with low, referent and high TG0 levels, respectively. Among women with prepregnancy body mass index
ISSN:2040-1116
2040-1124
DOI:10.1111/jdi.13273