Pandemic preparedness through vaccine development for avian influenza viruses

Influenza A viruses pose a significant threat to global health, impacting both humans and animals. Zoonotic transmission, particularly from swine and avian species, is the primary source of human influenza outbreaks. Notably, avian influenza viruses of the H5N1, H7N9, and H9N2 subtypes are of pandem...

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Bibliographic Details
Published in:Human vaccines & immunotherapeutics 2024-12, Vol.20 (1), p.2347019
Main Authors: Cargnin Faccin, Flavio, Perez, Daniel R
Format: Article
Language:English
Subjects:
Animals
avian influenza
Birds
Clinical Trials as Topic
Disease Models, Animal
Humans
Influenza A Virus, H5N1 Subtype - immunology
Influenza A Virus, H7N9 Subtype - immunology
Influenza A Virus, H9N2 Subtype - immunology
influenza a viruses
Influenza in Birds - epidemiology
Influenza in Birds - prevention & control
Influenza Vaccines - administration & dosage
Influenza Vaccines - immunology
Influenza, Human - epidemiology
Influenza, Human - immunology
Influenza, Human - prevention & control
Pandemic Preparedness
pandemic viruses
Pandemics - prevention & control
Vaccination
Vaccine Development
Vaccines
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Summary:Influenza A viruses pose a significant threat to global health, impacting both humans and animals. Zoonotic transmission, particularly from swine and avian species, is the primary source of human influenza outbreaks. Notably, avian influenza viruses of the H5N1, H7N9, and H9N2 subtypes are of pandemic concern through their global spread and sporadic human infections. Preventing and controlling these viruses is critical due to their high threat level. Vaccination remains the most effective strategy for influenza prevention and control in humans, despite varying vaccine efficacy across strains. This review focuses specifically on pandemic preparedness for avian influenza viruses. We delve into vaccines tested in animal models and summarize clinical trials conducted on H5N1, H7N9, and H9N2 vaccines in humans.
ISSN:2164-5515
2164-554X
2164-554X
DOI:10.1080/21645515.2024.2347019