The Post-Transcriptional Regulatory Element of Hepatitis B Virus: From Discovery to Therapy

The post-transcriptional regulatory element (PRE) is present in all HBV mRNAs and plays a major role in their stability, nuclear export, and enhancement of viral gene expression. Understanding PRE's structure, function, and mode of action is essential to leverage its potential as a therapeutic...

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Bibliographic Details
Published in:Viruses 2024-04, Vol.16 (4), p.528
Main Authors: Mouzannar, Karim, Schauer, Anne, Liang, T Jake
Format: Article
Language:English
Subjects:
Animals
Antigens
Antiviral Agents - pharmacology
Antiviral Agents - therapeutic use
Biotechnology
Care and treatment
Cytoplasm
Development and progression
Gene expression
Gene Expression Regulation, Viral
Gene therapy
Genes
Genetic aspects
Genetic transcription
Genomes
Health aspects
Hepatitis B
Hepatitis B - drug therapy
Hepatitis B - virology
Hepatitis B virus
Hepatitis B virus - genetics
Hepatitis B virus - physiology
Humans
Identification and classification
Leukemia
Liver cancer
Management
Medical research
Medicine, Experimental
Messenger RNA
Methods
Nuclear transport
Post-transcription
PRE
Proteins
Review
RNA
RNA Processing, Post-Transcriptional
RNA tailing
RNA, Messenger - genetics
RNA, Viral - genetics
RNA, Viral - metabolism
Structure-function relationships
TENT4A/B
Therapeutic targets
Viruses
ZCCHC14
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Description
Summary:The post-transcriptional regulatory element (PRE) is present in all HBV mRNAs and plays a major role in their stability, nuclear export, and enhancement of viral gene expression. Understanding PRE's structure, function, and mode of action is essential to leverage its potential as a therapeutic target. A wide range of PRE-based reagents and tools have been developed and assessed in preclinical and clinical settings for therapeutic and biotechnology applications. This manuscript aims to provide a systematic review of the characteristics and mechanism of action of PRE, as well as elucidating its current applications in basic and clinical research. Finally, we discuss the promising opportunities that PRE may provide to antiviral development, viral biology, and potentially beyond.
ISSN:1999-4915
1999-4915
DOI:10.3390/v16040528