The interplay of cells, polymers, and vascularization in three-dimensional lung models and their applications in COVID-19 research and therapy

Millions of people have been affected ever since the emergence of the corona virus disease of 2019 (COVID-19) outbreak, leading to an urgent need for antiviral drug and vaccine development. Current experimentation on traditional two-dimensional culture (2D) fails to accurately mimic the in vivo micr...

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Published in:Stem cell research & therapy 2023-04, Vol.14 (1), p.114-20, Article 114
Main Authors: Ahmed, Toka A, Eldaly, Bassant, Eldosuky, Shadwa, Elkhenany, Hoda, El-Derby, Azza M, Elshazly, Muhamed F, El-Badri, Nagwa
Format: Article
Language:English
Subjects:
Accuracy
Animal models
Animals
Antiviral agents
Biochips
Brain research
Cancer
Cell culture
Cell Culture Techniques - methods
Coronaviruses
COVID-19
Drug screening
Drug testing
Epidermal growth factor
Fibroblasts
Health aspects
Humans
Hydrogels
Infection
Infections
Kinases
Ligands
Lung
Lung organoid
Lung spheroid
Medical research
Medicine, Experimental
Methods
Microenvironments
Natural polymers
Neurophysiology
Neurosciences
Organoids
Pathogenesis
Physiology
Polymers
Respiratory syncytial virus
Review
Semiconductors
Severe acute respiratory syndrome coronavirus 2
Spheroids
Stem cells
Synthetic polymers
Vaccine development
Vaccines
Vascularization
Virus diseases
Viruses
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description Millions of people have been affected ever since the emergence of the corona virus disease of 2019 (COVID-19) outbreak, leading to an urgent need for antiviral drug and vaccine development. Current experimentation on traditional two-dimensional culture (2D) fails to accurately mimic the in vivo microenvironment for the disease, while in vivo animal model testing does not faithfully replicate human COVID-19 infection. Human-based three-dimensional (3D) cell culture models such as spheroids, organoids, and organ-on-a-chip present a promising solution to these challenges. In this report, we review the recent 3D in vitro lung models used in COVID-19 infection and drug screening studies and highlight the most common types of natural and synthetic polymers used to generate 3D lung models.
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subjects Accuracy
Animal models
Animals
Antiviral agents
Biochips
Brain research
Cancer
Cell culture
Cell Culture Techniques - methods
Coronaviruses
COVID-19
Drug screening
Drug testing
Epidermal growth factor
Fibroblasts
Health aspects
Humans
Hydrogels
Infection
Infections
Kinases
Ligands
Lung
Lung organoid
Lung spheroid
Medical research
Medicine, Experimental
Methods
Microenvironments
Natural polymers
Neurophysiology
Neurosciences
Organoids
Pathogenesis
Physiology
Polymers
Respiratory syncytial virus
Review
Semiconductors
Severe acute respiratory syndrome coronavirus 2
Spheroids
Stem cells
Synthetic polymers
Vaccine development
Vaccines
Vascularization
Virus diseases
Viruses
title The interplay of cells, polymers, and vascularization in three-dimensional lung models and their applications in COVID-19 research and therapy
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