Metformin relaxes rat thoracic aorta via nitric oxide, AMPK, potassium channels, and PKC

Objective(s): The present research aimed to identify the functional effects and underlying mechanisms of metformin on the rat thoracic aorta. Materials and Methods: Thoracic aorta segments of Wistar Albino rats were put in the chambers of an isolated tissue bath system. The resting tone was adjusted...

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Bibliographic Details
Published in:Iranian journal of basic medical sciences 2023-09, Vol.26 (9), p.1030-1040
Main Author: Sahinturk, Serdar
Format: Article
Language:English
Subjects:
Antidiabetics
Coronary vessels
Endothelium
metformin
Nitric oxide
Original
Potassium
potassium channels
rat
thoracic aorta
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Summary:Objective(s): The present research aimed to identify the functional effects and underlying mechanisms of metformin on the rat thoracic aorta. Materials and Methods: Thoracic aorta segments of Wistar Albino rats were put in the chambers of an isolated tissue bath system. The resting tone was adjusted to 1 g. Following the equilibration time, potassium chloride or phenylephrine was used to contract the vascular segments. The vessel segments were cumulatively treated with metformin (10-7–10-3 M) when a steady contraction was achieved. The described experimental approach was repeated after incubations with signaling pathway inhibitors and selective blockers of potassium channels to identify the effect mechanisms of metformin. Results: Metformin had a potent vasorelaxant effect in a concentration-dependent way (P
ISSN:2008-3866
2008-3874
DOI:10.22038/ijbms.2023.69728.15179