Effects of weight loss, induced by gastric bypass surgery, on HDL remodeling in obese women

• Published in: Journal of lipid research 2010-08, Vol.51 (8), p.2405-2412
• Main Authors: Asztalos, Bela F., Swarbrick, Michael M., Schaefer, Ernst J., Dallal, Gerard E., Horvath, Katalin V., Ai, Masumi, Stanhope, Kimber L., Austrheim-Smith, Iselin, Wolfe, Bruce M., Ali, Mohamed, Havel, Peter J.
• Format: Article
• Language: English
• Subjects: cardiovascular disease risk; glucose homeostasis; high density lipoprotein particles; lipoprotein metabolism
• ISSN: 0022-2275; 1539-7262
• DOI: 10.1194/jlr.P900015-JLR200

Plasma lipoproteins and glucose homeostasis were evaluated after marked weight loss before and over 12 months following Roux-en-Y gastric-bypass (RYGBP) surgery in 19 morbidly obese women. Standard lipids, remnant-lipoprotein cholesterol (RLP-C); HDL-triglyceride (TG); apolipoproteins (apo) A-I, A-II, E, and A-I-containing HDL subpopulations; lecithin-cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) mass and activity; plasma glucose and insulin levels were measured before and at 1, 3, 6, and 12 months after GBP surgery. Baseline concentrations of TG, RLP-C, glucose, and insulin were significantly higher in obese than in normal-weight, age-matched women, whereas HDL cholesterol (HDL-C), apoA-I, apoA-II, α-1 and α-2 levels were significantly lower. Over 1 year, significant decreases of body mass index, glucose, insulin, TG, RLP-C, HDL-TG, and preβ-1 levels were observed with significant increases of HDL-C and α-1 levels (all P < 0.05). Changes of fat mass were correlated with those of LDL cholesterol (P = 0.018) and LCAT mass (P = 0.011), but not with CETP mass (P = 0.265). Changes of fasting plasma glucose concentrations were inversely correlated with those of CETP mass (P = 0.005) and α-1 level (P = 0.004). Changes of fasting plasma insulin concentrations were positively correlated with those of LCAT mass (P = 0.043) and inversely with changes of α-1 (P = 0.03) and α-2 (P = 0.05) concentrations. These results demonstrate beneficial changes in HDL remodeling following substantial weight loss induced by RYGBP surgery and that these changes are associated with improvement of glucose homeostasis in these patients.