Fabrication of Pillar Shaped Electrode Arrays for Artificial Retinal Implants

Polyimide has been widely applied to neural prosthetic devices, such as the retinal implants, due to its well-known biocompatibility and ability to be micropatterned. However, planar films of polyimide that are typically employed show a limited ability in reducing the distance between electrodes and...

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Bibliographic Details
Published in:Sensors (Basel, Switzerland) Switzerland), 2008-09, Vol.8 (9), p.5845-5856
Main Authors: Kim, Eui Tae, Seo, Jong-Mo, Woo, Se Joon, Zhou, Jing Ai, Chung, Hum, Kim, Sung June
Format: Article
Language:English
Subjects:
Arrays
Clinical trials
Computer engineering
electrically evoked cortical potential
Electrodes
Gold
Ophthalmology
optical coherence tomography
Optics
pillar
Plasma etching
Polyimide
Prostheses
retinal implant
Sensors
Silicon wafers
Titanium
Tomography
Transplants & implants
Visual acuity
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Summary:Polyimide has been widely applied to neural prosthetic devices, such as the retinal implants, due to its well-known biocompatibility and ability to be micropatterned. However, planar films of polyimide that are typically employed show a limited ability in reducing the distance between electrodes and targeting cell layers, which limits site resolution for effective multi-channel stimulation. In this paper, we report a newly designed device with a pillar structure that more effectively interfaces with the target. Electrode arrays were successfully fabricated and safely implanted inside the rabbit eye in suprachoroidal space. Optical Coherence Tomography (OCT) showed well-preserved pillar structures of the electrode without damage. Bipolar stimulation was applied through paired sites (6:1) and the neural responses were successfully recorded from several regions in the visual cortex. Electrically evoked cortical potential by the pillar electrode array stimulation were compared to visual evoked potential under full-field light stimulation.
ISSN:1424-8220
1424-8220
DOI:10.3390/s8095845