Moisturizing effects of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) using deionized and magnetized water by in vivo and in vitro methods

The present study aimed to determine and compare moisturizing and occlusion effects of different solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) using magnetized water and deionized water. SLN formulations were prepared using various lipids, including Tripalmitin, Compritol®,...

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Bibliographic Details
Published in:Iranian journal of basic medical sciences 2020-03, Vol.23 (3), p.337-343
Main Authors: Sarhadi, Susan, Gholizadeh, Mostafa, Moghadasian, Tina, Golmohammadzadeh, Shiva
Format: Article
Language:English
Subjects:
deionized water
Homogenization
Lipids
Magnetic fields
magnetized water
Microscopy
Nanoparticles
Nanotechnology
nlc
Original
Particle size
Pharmaceutical sciences
Skin
skin dryness
sln
Studies
Ultrasonic imaging
Viscosity
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Summary:The present study aimed to determine and compare moisturizing and occlusion effects of different solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) using magnetized water and deionized water. SLN formulations were prepared using various lipids, including Tripalmitin, Compritol®, Precirol®, and emulsifiers including Poloxamer and Tween 80. NLC formulations were also prepared with oleic acid and the same solid lipids. Two types of formulations were prepared; first with deionized water and then with magnetized water. Formulations were prepared using high shear homogenization and ultrasound methods. The products were analyzed by PSA (particle size analyzer), DSC (differential scanning calorimetry), and TEM (transmission electron microscopy). The moisturizing effect of formulations was determined by and methods. Findings of the assessments demonstrated that in products prepared with magnetized water, 5% SLN Precirol® had the most moisturizing effect and 5% SLN Compritol® had the most moisturizing effect . The use of magnetized water in formulations can improve the effectiveness and increase the stability of moisturizing products. In this study, all products prepared with magnetized water showed more stability, smaller size, and more moisturizing effects compared with products prepared with deionized water.
ISSN:2008-3866
2008-3874
DOI:10.22038/IJBMS.2020.39587.9397