Post-reperfusion acute MR diffusion in stroke is a potential predictor for clinical outcome in rats

Middle cerebral artery occlusion (MCAO) models show substantial variability in outcome, introducing uncertainties in the evaluation of treatment effects. Early outcome predictors would be essential for prognostic purposes and variability control. We aimed to compare apparent diffusion coefficient (A...

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Bibliographic Details
Published in:Scientific reports 2023-04, Vol.13 (1), p.5598-5598, Article 5598
Main Authors: Nagy, Szilvia Anett, Ivic, Ivan, Tóth, Péter, Komoly, Sámuel, Kiss, Tamás, Pénzes, Máté, Málnási-Csizmadia, András, Dóczi, Tamás, Perlaki, Gábor, Orsi, Gergely
Format: Article
Language:English
Subjects:
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Animals
Behavior
Biochemistry
Brain Ischemia - pathology
Cerebral blood flow
Clinical outcomes
Diffusion
Diffusion coefficient
Diffusion Magnetic Resonance Imaging
Disease Models, Animal
Humanities and Social Sciences
Infarction, Middle Cerebral Artery - pathology
Ischemia
Lesions
Magnetic Resonance Imaging
Male
Medical prognosis
Medical research
multidisciplinary
Neurosciences
Rats
Reperfusion
Science
Science (multidisciplinary)
Stroke
Survival
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Summary:Middle cerebral artery occlusion (MCAO) models show substantial variability in outcome, introducing uncertainties in the evaluation of treatment effects. Early outcome predictors would be essential for prognostic purposes and variability control. We aimed to compare apparent diffusion coefficient (ADC) MRI data obtained during MCAO and shortly after reperfusion for their potentials in acute-phase outcome prediction. Fifty-nine male rats underwent a 45-min MCAO. Outcome was defined in three ways: 21-day survival; 24 h midline-shift and neurological scores. Animals were divided into two groups: rats surviving 21 days after MCAO (survival group, n = 46) and rats dying prematurely (non-survival/NS group, n = 13). At reperfusion, NS group showed considerably larger lesion volume and lower mean ADC of the initial lesion site (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-32679-1