The role of MRI and clinicopathologic features in predicting the invasive component of biopsy-confirmed ductal carcinoma in situ

• Published in: BMC medical imaging 2020-08, Vol.20 (1), p.1-95, Article 95
• Main Authors: Yoon, Ga Young, Choi, Woo Jung, Cha, Joo Hee, Shin, Hee Jung, Chae, Eun Young, Kim, Hak Hee
• Format: Article
• Language: English
• Subjects: Biopsy; Breast; Breast cancer; Breasts; Cancer; Comparative analysis; Confidence intervals; Ductal carcinoma in situ; Edema; Gadoterate meglumine; Gene amplification; Invasive ductal carcinoma; Invasive ductal carcinoma (Breast cancer); Invasiveness; Lesions; Magnetic resonance imaging; Medical research; MRI; Multivariate analysis; Pathology; Patients; Progesterone; Regression analysis; Scanners; Statistical analysis; Variables
• ISSN: 1471-2342; 1471-2342
• DOI: 10.1186/s12880-020-00494-z

Background The upgrade rate of biopsy-confirmed ductal carcinoma in situ (DCIS) to invasive carcinoma is up to 50% on final pathology. We investigated MRI and clinicopathologic predictors of the invasive components of DCIS diagnosed by preoperative biopsy and then compared MRI features between patients with DCIS, microinvasive ductal carcinoma (mIDC), and invasive ductal carcinoma (IDC) diagnosed on final pathology. Methods Two hundred and one patients with 206 biopsy-confirmed DCIS lesions were enrolled. MRI and clinicopathologic features were used to predict either mIDC or IDC via a cumulative logistic regression analysis. For the lesions detected on MRI, morphologic and kinetic analyses were performed using the Chi-square, Fisher's exact, and Kruskal-Wallis tests. Results Of all the lesions, 112 (54.4%) were diagnosed as DCIS, 50 (24.3%) were upgraded to mIDC, and 44 (21.4%) to IDC. The detection on MRI as mass (Odds ratio (OR) = 8.84, 95% confidence interval (CI) = 1.05-74.04, P = 0.045) or non-mass enhancement (NME; OR = 11.17, 95% CI = 1.35-92.36, P = 0.025), negative progesterone receptor (PR; OR = 2.40, 95% CI = 1.29-4.44, P = 0.006), and high Ki-67 level (OR = 2.42, 95% CI = 1.30-4.50, P = 0.005) were significant independent predictors of histologic upgrade. On MRI, 87 (42.2%) lesions appeared as mass and 107 (51.9%) as NME. Irregularly shaped, not-circumscribed, heterogeneous, or rim-enhancing masses with intratumoral high signal intensity or peritumoral edema, clumped or clustered ring-enhancing NMEs, and high peak enhancement were significantly associated with histologic upgrade (P < 0.001). Conclusion MRI detection, negative PR, and high Ki-67 levels are associated with a histologic upgrade in patients with biopsy-confirmed DCIS. Suspicious MRI features are more frequent in such patients. Keywords: Breast, MRI, Ductal carcinoma in situ, Invasive ductal carcinoma