The Association between the Activin A Serum Level and Carotid Intima-Media Thickness in Chronic Kidney Disease Patients

Introduction. Chronic kidney disease (CKD) is associated with high mortality rates, mainly as a result of cardiovascular complications. Meanwhile, recent studies have suggested a role of a homodimer protein called activin A in chronic kidney disease-mineral and bone disorder (CKD-MBD) conditions tha...

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Bibliographic Details
Published in:International journal of nephrology 2020-11, Vol.2020 (2020), p.1-5
Main Authors: Suprapti, Suprapti, Effendi, Ian, Bahar, Erial, Indrajaya, Taufik, Ali, Zulkhair, Yonata, Ade, Suhaimi, Novadian
Format: Article
Language:English
Subjects:
Age
Biomarkers
Body mass index
Calcification
Chronic kidney failure
Creatinine
Diabetes
Enzyme-linked immunosorbent assay
Growth factors
Health aspects
Hemodialysis
Hypertension
Indonesia
Kidney diseases
Laboratories
Medical research
Medicine, Experimental
Mortality
Multivariate analysis
Pathogenesis
Patients
Phosphates
Population
Proteins
Regression analysis
Sepsis
Standard deviation
Triglycerides
Type 2 diabetes
Values
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Summary:Introduction. Chronic kidney disease (CKD) is associated with high mortality rates, mainly as a result of cardiovascular complications. Meanwhile, recent studies have suggested a role of a homodimer protein called activin A in chronic kidney disease-mineral and bone disorder (CKD-MBD) conditions that may exist in the vascular calcification and osteolytic process. Ultrasound examination of the carotid intima-media thickness (cIMT) is a noninvasive method to assess vascular calcification. This study aimed to analyze the relationship between the activin A serum level and cIMT in patients with CKD at Mohammad Hoesin Hospital, Palembang, Indonesia. Methods. We conducted a hospital-based, cross-sectional study of consecutive CKD patients at the Department of Internal Medicine, Mohammad Hoesin Hospital, from July to November 2019. The level of activin A was measured by enzyme-linked immunosorbent assay. Meanwhile, cIMT measurements were collected by B-mode ultrasound imaging. Results. A total of 55 patients with CKD were included in this investigation. The median serum activin A level in these patients was 236.17 (116.33–283) pg/mL, while the median cIMT was 0.8 (0.6–1.45) mm. A relationship between the serum activin A level and cIMT (r = 0.449; p=0.001) was observed. During multivariate analysis with linear regression, triglyceride p=0.049, phosphate p=0.005, and activin A p=0.020 serum levels were factors associated with cIMT. Conclusion. In this study, a relationship between the activin A serum level and cIMT in patients with CKD was identified. Vascular calcification should be screened for in all CKD patients by the measurement of cIMT.
ISSN:2090-214X
2090-2158
2090-2158
DOI:10.1155/2020/8893653