Inhibitory effect and mechanism of Lactobacillus crispatus on cervical precancerous cells Ect1/E6E7 and screening of early warning factors

To study the potential mechanism of Lactobacillus crispatus inhibiting cervical squamous intraepithelial lesion (SIL) and screen the early warning factors of SIL. The effects of Lactobacillus crispatus on the proliferation, apoptosis, cross pore migration and invasion and cytokines of cervical preca...

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Bibliographic Details
Published in:Infectious agents and cancer 2023-02, Vol.18 (1), p.5-5, Article 5
Main Authors: Wan, B, Wei, L J, Tan, T M, Qin, L, Wang, H
Format: Article
Language:English
Subjects:
Antibiotics
Apoptosis
Cell migration
Cell proliferation
Cells
Cervical intraepithelial lesions
Chromosomal proteins
Co-culture
Cytokines
Differential protein
Early warning factor
HMGB1 protein
Human papillomavirus
Infections
Lactobacillus crispatus
Linear equations
Lymphocytes T
OGG1 protein
Proliferating cell nuclear antigen
Proteins
Statistical analysis
Vagina
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Summary:To study the potential mechanism of Lactobacillus crispatus inhibiting cervical squamous intraepithelial lesion (SIL) and screen the early warning factors of SIL. The effects of Lactobacillus crispatus on the proliferation, apoptosis, cross pore migration and invasion and cytokines of cervical precancerous cells Ect1/E6E7 were detected respectively. The effect of Lactobacillus crispatus on the expression of differential proteins screened in Ect1/E6E7 cells were detected by Western blot. Lactobacillus crispatus significantly inhibited the proliferation, induced apoptosis and inhibited cell migration of Ect1/E6E7 cells in a time-dependent manner (P 
ISSN:1750-9378
1750-9378
DOI:10.1186/s13027-023-00483-1