Exploitation of Quercetin's Antioxidative Properties in Potential Alternative Therapeutic Options for Neurodegenerative Diseases

Oxidative stress (OS) is a condition in which there is an excess of reactive oxygen species (ROS) in the body, which can lead to cell and tissue damage. This occurs when there is an overproduction of ROS or when the body's antioxidant defense systems are overwhelmed. Quercetin (Que) is part of...

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Bibliographic Details
Published in:Antioxidants 2023-07, Vol.12 (7), p.1418
Main Authors: Rarinca, Viorica, Nicoara, Mircea Nicusor, Ureche, Dorel, Ciobica, Alin
Format: Article
Language:English
Subjects:
Age
Alzheimer's disease
Anti-inflammatory agents
Antioxidants
Cognitive ability
Dementia
Deoxyribonucleic acid
DNA
Epilepsy
Flavonoids
Fruits
Health aspects
Homeostasis
Huntington's disease
Huntingtons disease
Inflammation
Ischemia
Isoflavones
Metabolism
Metabolites
Movement disorders
Nervous system diseases
Neurodegeneration
Neurodegenerative diseases
Neurons
Neurophysiology
Neuroprotection
neuroprotective effects
Oxidative stress
Parkinson's disease
Proteins
Quercetin
Radiation
Reactive oxygen species
Review
Vegetables
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Summary:Oxidative stress (OS) is a condition in which there is an excess of reactive oxygen species (ROS) in the body, which can lead to cell and tissue damage. This occurs when there is an overproduction of ROS or when the body's antioxidant defense systems are overwhelmed. Quercetin (Que) is part of a group of compounds called flavonoids. It is found in high concentrations in vegetables, fruits, and other foods. Over the past decade, a growing number of studies have highlighted the therapeutic potential of flavonoids to modulate neuronal function and prevent age-related neurodegeneration. Therefore, Que has been shown to have antioxidant, anticancer, and anti-inflammatory properties, both in vitro and in vivo. Due to its antioxidant character, Que alleviates oxidative stress, thus improving cognitive function, reducing the risk of neurodegenerative diseases. On the other hand, Que can also help support the body's natural antioxidant defense systems, thus being a potentially practical supplement for managing OS. This review focuses on experimental studies supporting the neuroprotective effects of Que in Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and epilepsy.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox12071418