Ethanol Dehydrogenase I Contributes to Growth and Sporulation Under Low Oxygen Condition via Detoxification of Acetaldehyde in Metarhizium acridum

The entomopathogenic fungi encounter hypoxic conditions in both nature and artificial culture. Alcohol dehydrogenases (ADHs) are a group of oxidoreductases that occur in many organisms. Here we demonstrate that an alcohol dehydrogenase I, , in the locust-specific fungal pathogen, , functions in acet...

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Bibliographic Details
Published in:Frontiers in microbiology 2018-08, Vol.9, p.1932-1932
Main Authors: Zhang, Erhao, Cao, Yueqing, Xia, Yuxian
Format: Article
Language:English
Subjects:
conidiation
entomopathogenic fungi
ethanol dehydrogenase
growth
hypoxic condition
Microbiology
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Summary:The entomopathogenic fungi encounter hypoxic conditions in both nature and artificial culture. Alcohol dehydrogenases (ADHs) are a group of oxidoreductases that occur in many organisms. Here we demonstrate that an alcohol dehydrogenase I, , in the locust-specific fungal pathogen, , functions in acetaldehyde detoxification mechanism under hypoxic conditions in growth and sporulation. The was highly expressed in sporulation stage under hypoxic conditions. Compared with a wild-type strain, the Δ mutant showed inhibited growth and sporulation under hypoxic conditions, but no impairment under normal conditions. Under hypoxic conditions, Δ mutant produced significant decreased alcohol, but significant increased acetaldehyde compared to wild type. was sensitive to exogenous acetaldehyde, exhibiting an inhibited growth and sporulation with acetaldehyde added in the medium. MaADH1 did not affect virulence. Our results indicated that the was critical to growth and sporulation under hypoxic stress by detoxification of acetaldehyde in .
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2018.01932