Programming assembly of biomimetic exosomes: An emerging theranostic nanomedicine platform

Exosomes have emerged as a promising cell-free therapeutic approach. However, challenges in large-scale production, quality control, and heterogeneity must be overcome before they can be used clinically. Biomimetic exosomes containing key components of natural exosomes have been assembled through ex...

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Bibliographic Details
Published in:Materials today bio 2023-10, Vol.22, p.100760-100760, Article 100760
Main Authors: Xu, Xiao, Xu, Limei, Wen, Caining, Xia, Jiang, Zhang, Yuanmin, Liang, Yujie
Format: Article
Language:English
Subjects:
Biomimetic exosomes
Drug delivery
Exosome-mimetics (EMs)
Exosomes
Hybrid exosomes
Nanomedicine
Review
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Summary:Exosomes have emerged as a promising cell-free therapeutic approach. However, challenges in large-scale production, quality control, and heterogeneity must be overcome before they can be used clinically. Biomimetic exosomes containing key components of natural exosomes have been assembled through extrusion, artificial synthesis, and liposome fusion to address these limitations. These exosome-mimetics (EMs) possess similar morphology and function but provide higher yields, faster large-scale production, and similar size compared to conventional exosomes. This article provides an overview of the chemical and biological properties of various synthetic exosome systems, including nanovesicles (NVs), EMs, and hybrid exosomes. We highlight recent advances in the production and applications of nanobiotechnology and discuss the advantages, limitations, and potential clinical applications of programming assembly of exosome mimetics. Approaches for the development of biomimetic exosomes as nonotheranostic platform. Image 1
ISSN:2590-0064
2590-0064
DOI:10.1016/j.mtbio.2023.100760