Review: Ischemia Reperfusion Injury-A Translational Perspective in Organ Transplantation

Thanks to the development of new, more potent and selective immunosuppressive drugs together with advances in surgical techniques, organ transplantation has emerged from an experimental surgery over fifty years ago to being the treatment of choice for many end-stage organ diseases, with over 139,000...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-11, Vol.21 (22), p.8549
Main Authors: Fernández, André Renaldo, Sánchez-Tarjuelo, Rodrigo, Cravedi, Paolo, Ochando, Jordi, López-Hoyos, Marcos
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Blood flow
Cell death
cell metabolism
Drug development
Grafting
Humans
Hypoxia
Immune response
Immune system
Immunosuppressive agents
Immunosuppressive Agents - therapeutic use
innate immunity
Ischemia
ischemia reperfusion injury
Lipid peroxidation
Metabolism
Organ Preservation
Organ Transplantation
Oxidative stress
Reperfusion
Reperfusion Injury - immunology
Reperfusion Injury - prevention & control
Review
RNA interference
Surgery
Transplantation
Transplants
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Summary:Thanks to the development of new, more potent and selective immunosuppressive drugs together with advances in surgical techniques, organ transplantation has emerged from an experimental surgery over fifty years ago to being the treatment of choice for many end-stage organ diseases, with over 139,000 organ transplants performed worldwide in 2019. Inherent to the transplantation procedure is the fact that the donor organ is subjected to blood flow cessation and ischemia during harvesting, which is followed by preservation and reperfusion of the organ once transplanted into the recipient. Consequently, ischemia/reperfusion induces a significant injury to the graft with activation of the immune response in the recipient and deleterious effect on the graft. The purpose of this review is to discuss and shed new light on the pathways involved in ischemia/reperfusion injury (IRI) that act at different stages during the donation process, surgery, and immediate post-transplant period. Here, we present strategies that combine various treatments targeted at different mechanistic pathways during several time points to prevent graft loss secondary to the inflammation caused by IRI.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21228549