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The fatal contribution of serine protease-related genetic variants to COVID-19 outcomes
Serine proteases play a critical role during SARS-CoV-2 infection. Therefore, polymorphisms of transmembrane protease serine 2 ( ) and serpine family E member 1 ( ) could help to elucidate the contribution of variability to COVID-19 outcomes. To evaluate the genetic variants of the genes previously...
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Published in: | Frontiers in immunology 2024-03, Vol.15, p.1335963-1335963 |
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creator | Martínez-Gómez, Laura Edith Martinez-Armenta, Carlos Tusie-Luna, Teresa Vázquez-Cárdenas, Paola Vidal-Vázquez, Rosa P Ramírez-Hinojosa, Juan P Gómez-Martín, Diana Vargas-Alarcón, Gilberto Posadas-Sánchez, Rosalinda Fragoso, José Manuel de la Peña, Aurora Rodríguez-Pérez, José Manuel Mata-Miranda, Mónica M Vázquez-Zapién, Gustavo J Martínez-Cuazitl, Adriana Martínez-Ruiz, Felipe de J Zayago-Angeles, Dulce M Ramos-Tavera, Luis Méndez-Aguilera, Alberto Camacho-Rea, María Del C Ordoñez-Sánchez, María L Segura-Kato, Yayoi Suarez-Ahedo, Carlos Olea-Torres, Jessel Herrera-López, Brígida Pineda, Carlos Martínez-Nava, Gabriela A López-Reyes, Alberto |
description | Serine proteases play a critical role during SARS-CoV-2 infection. Therefore, polymorphisms of transmembrane protease serine 2 (
) and serpine family E member 1 (
) could help to elucidate the contribution of variability to COVID-19 outcomes.
To evaluate the genetic variants of the genes previously associated with COVID-19 outcomes, we performed a cross-sectional study in which 1536 SARS-CoV-2-positive participants were enrolled.
(rs2070788, rs75603675, rs12329760) and
(rs2227631, rs2227667, rs2070682, rs2227692) were genotyped using the Open Array Platform. The association of polymorphisms with disease outcomes was determined by logistic regression analysis adjusted for covariates (age, sex, hypertension, type 2 diabetes, and obesity).
According to our codominant model, the GA genotype of rs2227667 (OR=0.55; 95% CI = 0.36-0.84;
=0.006) and the AG genotype of rs2227667 (OR=0.59; 95% CI = 0.38-0.91;
=0.02) of
played a protective role against disease. However, the rs2227692 T allele and TT genotype
(OR=1.45; 95% CI = 1.11-1.91;
=0.006; OR=2.08; 95% CI = 1.22-3.57;
=0.007; respectively) were associated with a decreased risk of death. Similarly, the rs75603675 AA genotype
had an OR of 1.97 (95% CI = 1.07-3.6;
=0.03) for deceased patients. Finally, the rs2227692 T allele
was associated with increased D-dimer levels (OR=1.24; 95% CI = 1.03-1.48;
=0.02).
Our data suggest that the rs75603675
and rs2227692
polymorphisms are associated with a poor outcome. Additionally, rs2227692
could participate in hypercoagulable conditions in critical COVID-19 patients, and this genetic variant could contribute to the identification of new pharmacological targets and treatment strategies to block the inhibition of TMPRSS2 entry into SARS-CoV-2. |
doi_str_mv | 10.3389/fimmu.2024.1335963 |
format | article |
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) and serpine family E member 1 (
) could help to elucidate the contribution of variability to COVID-19 outcomes.
To evaluate the genetic variants of the genes previously associated with COVID-19 outcomes, we performed a cross-sectional study in which 1536 SARS-CoV-2-positive participants were enrolled.
(rs2070788, rs75603675, rs12329760) and
(rs2227631, rs2227667, rs2070682, rs2227692) were genotyped using the Open Array Platform. The association of polymorphisms with disease outcomes was determined by logistic regression analysis adjusted for covariates (age, sex, hypertension, type 2 diabetes, and obesity).
According to our codominant model, the GA genotype of rs2227667 (OR=0.55; 95% CI = 0.36-0.84;
=0.006) and the AG genotype of rs2227667 (OR=0.59; 95% CI = 0.38-0.91;
=0.02) of
played a protective role against disease. However, the rs2227692 T allele and TT genotype
(OR=1.45; 95% CI = 1.11-1.91;
=0.006; OR=2.08; 95% CI = 1.22-3.57;
=0.007; respectively) were associated with a decreased risk of death. Similarly, the rs75603675 AA genotype
had an OR of 1.97 (95% CI = 1.07-3.6;
=0.03) for deceased patients. Finally, the rs2227692 T allele
was associated with increased D-dimer levels (OR=1.24; 95% CI = 1.03-1.48;
=0.02).
Our data suggest that the rs75603675
and rs2227692
polymorphisms are associated with a poor outcome. Additionally, rs2227692
could participate in hypercoagulable conditions in critical COVID-19 patients, and this genetic variant could contribute to the identification of new pharmacological targets and treatment strategies to block the inhibition of TMPRSS2 entry into SARS-CoV-2.</description><identifier>ISSN: 1664-3224</identifier><identifier>EISSN: 1664-3224</identifier><identifier>DOI: 10.3389/fimmu.2024.1335963</identifier><identifier>PMID: 38601158</identifier><language>eng</language><publisher>Switzerland: Frontiers Media S.A</publisher><subject>COVID-19 ; Immunology ; Polymorphism ; SARS-CoV-2 ; SERPINE1 ; TMPRSS2</subject><ispartof>Frontiers in immunology, 2024-03, Vol.15, p.1335963-1335963</ispartof><rights>Copyright © 2024 Martínez-Gómez, Martinez-Armenta, Tusie-Luna, Vázquez-Cárdenas, Vidal-Vázquez, Ramírez-Hinojosa, Gómez-Martín, Vargas-Alarcón, Posadas-Sánchez, Fragoso, de la Peña, Rodríguez-Pérez, Mata-Miranda, Vázquez-Zapién, Martínez-Cuazitl, Martínez-Ruiz, Zayago-Angeles, Ramos-Tavera, Méndez-Aguilera, Camacho-Rea, Ordoñez-Sánchez, Segura-Kato, Suarez-Ahedo, Olea-Torres, Herrera-López, Pineda, Martínez-Nava and López-Reyes.</rights><rights>Copyright © 2024 Martínez-Gómez, Martinez-Armenta, Tusie-Luna, Vázquez-Cárdenas, Vidal-Vázquez, Ramírez-Hinojosa, Gómez-Martín, Vargas-Alarcón, Posadas-Sánchez, Fragoso, de la Peña, Rodríguez-Pérez, Mata-Miranda, Vázquez-Zapién, Martínez-Cuazitl, Martínez-Ruiz, Zayago-Angeles, Ramos-Tavera, Méndez-Aguilera, Camacho-Rea, Ordoñez-Sánchez, Segura-Kato, Suarez-Ahedo, Olea-Torres, Herrera-López, Pineda, Martínez-Nava and López-Reyes 2024 Martínez-Gómez, Martinez-Armenta, Tusie-Luna, Vázquez-Cárdenas, Vidal-Vázquez, Ramírez-Hinojosa, Gómez-Martín, Vargas-Alarcón, Posadas-Sánchez, Fragoso, de la Peña, Rodríguez-Pérez, Mata-Miranda, Vázquez-Zapién, Martínez-Cuazitl, Martínez-Ruiz, Zayago-Angeles, Ramos-Tavera, Méndez-Aguilera, Camacho-Rea, Ordoñez-Sánchez, Segura-Kato, Suarez-Ahedo, Olea-Torres, Herrera-López, Pineda, Martínez-Nava and López-Reyes</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c420t-5c683966a1eb16fc5c3a5cd0f1440b87a6f84df508c61470a065ce16474628563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11004237/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11004237/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38601158$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martínez-Gómez, Laura Edith</creatorcontrib><creatorcontrib>Martinez-Armenta, Carlos</creatorcontrib><creatorcontrib>Tusie-Luna, Teresa</creatorcontrib><creatorcontrib>Vázquez-Cárdenas, Paola</creatorcontrib><creatorcontrib>Vidal-Vázquez, Rosa P</creatorcontrib><creatorcontrib>Ramírez-Hinojosa, Juan P</creatorcontrib><creatorcontrib>Gómez-Martín, Diana</creatorcontrib><creatorcontrib>Vargas-Alarcón, Gilberto</creatorcontrib><creatorcontrib>Posadas-Sánchez, Rosalinda</creatorcontrib><creatorcontrib>Fragoso, José Manuel</creatorcontrib><creatorcontrib>de la Peña, Aurora</creatorcontrib><creatorcontrib>Rodríguez-Pérez, José Manuel</creatorcontrib><creatorcontrib>Mata-Miranda, Mónica M</creatorcontrib><creatorcontrib>Vázquez-Zapién, Gustavo J</creatorcontrib><creatorcontrib>Martínez-Cuazitl, Adriana</creatorcontrib><creatorcontrib>Martínez-Ruiz, Felipe de J</creatorcontrib><creatorcontrib>Zayago-Angeles, Dulce M</creatorcontrib><creatorcontrib>Ramos-Tavera, Luis</creatorcontrib><creatorcontrib>Méndez-Aguilera, Alberto</creatorcontrib><creatorcontrib>Camacho-Rea, María Del C</creatorcontrib><creatorcontrib>Ordoñez-Sánchez, María L</creatorcontrib><creatorcontrib>Segura-Kato, Yayoi</creatorcontrib><creatorcontrib>Suarez-Ahedo, Carlos</creatorcontrib><creatorcontrib>Olea-Torres, Jessel</creatorcontrib><creatorcontrib>Herrera-López, Brígida</creatorcontrib><creatorcontrib>Pineda, Carlos</creatorcontrib><creatorcontrib>Martínez-Nava, Gabriela A</creatorcontrib><creatorcontrib>López-Reyes, Alberto</creatorcontrib><title>The fatal contribution of serine protease-related genetic variants to COVID-19 outcomes</title><title>Frontiers in immunology</title><addtitle>Front Immunol</addtitle><description>Serine proteases play a critical role during SARS-CoV-2 infection. Therefore, polymorphisms of transmembrane protease serine 2 (
) and serpine family E member 1 (
) could help to elucidate the contribution of variability to COVID-19 outcomes.
To evaluate the genetic variants of the genes previously associated with COVID-19 outcomes, we performed a cross-sectional study in which 1536 SARS-CoV-2-positive participants were enrolled.
(rs2070788, rs75603675, rs12329760) and
(rs2227631, rs2227667, rs2070682, rs2227692) were genotyped using the Open Array Platform. The association of polymorphisms with disease outcomes was determined by logistic regression analysis adjusted for covariates (age, sex, hypertension, type 2 diabetes, and obesity).
According to our codominant model, the GA genotype of rs2227667 (OR=0.55; 95% CI = 0.36-0.84;
=0.006) and the AG genotype of rs2227667 (OR=0.59; 95% CI = 0.38-0.91;
=0.02) of
played a protective role against disease. However, the rs2227692 T allele and TT genotype
(OR=1.45; 95% CI = 1.11-1.91;
=0.006; OR=2.08; 95% CI = 1.22-3.57;
=0.007; respectively) were associated with a decreased risk of death. Similarly, the rs75603675 AA genotype
had an OR of 1.97 (95% CI = 1.07-3.6;
=0.03) for deceased patients. Finally, the rs2227692 T allele
was associated with increased D-dimer levels (OR=1.24; 95% CI = 1.03-1.48;
=0.02).
Our data suggest that the rs75603675
and rs2227692
polymorphisms are associated with a poor outcome. Additionally, rs2227692
could participate in hypercoagulable conditions in critical COVID-19 patients, and this genetic variant could contribute to the identification of new pharmacological targets and treatment strategies to block the inhibition of TMPRSS2 entry into SARS-CoV-2.</description><subject>COVID-19</subject><subject>Immunology</subject><subject>Polymorphism</subject><subject>SARS-CoV-2</subject><subject>SERPINE1</subject><subject>TMPRSS2</subject><issn>1664-3224</issn><issn>1664-3224</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkU1r3DAQhkVpaUKaP9BD0bEXb_Ut-1TK9mshkEvaHsWsPNoo2NZWkgP593V2tyHRZYTmnUcv8xLynrOVlG33KcRxnFeCCbXiUurOyFfknBujGimEev3sfkYuS7ljy1GdXKRvyZlsDeNct-fkz80t0gAVBurTVHPczjWmiaZAC-Y4Id3nVBEKNhkHqNjTHU5Yo6f3kCNMtdCa6Pr69-Zrwzua5urTiOUdeRNgKHh5qhfk1_dvN-ufzdX1j836y1XjlWC10d60sjMGOG65CV57Cdr3LHCl2La1YEKr-qBZ6w1XlgEz2iM3yiojWm3kBdkcuX2CO7fPcYT84BJEd3hIeecgL24HdBIt071nprNS2Q4AfEBhfdCBoxV8YX0-svbzdsTe47IPGF5AX3ameOt26d5xvuxWSLsQPp4IOf2dsVQ3xuJxGGDCNBcn2SLqrD0YF0epz6mUjOHpH87cY8LukLB7TNidEl6GPjx3-DTyP0_5Dy1ropY</recordid><startdate>20240327</startdate><enddate>20240327</enddate><creator>Martínez-Gómez, Laura Edith</creator><creator>Martinez-Armenta, Carlos</creator><creator>Tusie-Luna, Teresa</creator><creator>Vázquez-Cárdenas, Paola</creator><creator>Vidal-Vázquez, Rosa P</creator><creator>Ramírez-Hinojosa, Juan P</creator><creator>Gómez-Martín, Diana</creator><creator>Vargas-Alarcón, Gilberto</creator><creator>Posadas-Sánchez, Rosalinda</creator><creator>Fragoso, José Manuel</creator><creator>de la Peña, Aurora</creator><creator>Rodríguez-Pérez, José Manuel</creator><creator>Mata-Miranda, Mónica M</creator><creator>Vázquez-Zapién, Gustavo J</creator><creator>Martínez-Cuazitl, Adriana</creator><creator>Martínez-Ruiz, Felipe de J</creator><creator>Zayago-Angeles, Dulce M</creator><creator>Ramos-Tavera, Luis</creator><creator>Méndez-Aguilera, Alberto</creator><creator>Camacho-Rea, María Del C</creator><creator>Ordoñez-Sánchez, María L</creator><creator>Segura-Kato, Yayoi</creator><creator>Suarez-Ahedo, Carlos</creator><creator>Olea-Torres, Jessel</creator><creator>Herrera-López, Brígida</creator><creator>Pineda, Carlos</creator><creator>Martínez-Nava, Gabriela A</creator><creator>López-Reyes, Alberto</creator><general>Frontiers Media S.A</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20240327</creationdate><title>The fatal contribution of serine protease-related genetic variants to COVID-19 outcomes</title><author>Martínez-Gómez, Laura Edith ; Martinez-Armenta, Carlos ; Tusie-Luna, Teresa ; Vázquez-Cárdenas, Paola ; Vidal-Vázquez, Rosa P ; Ramírez-Hinojosa, Juan P ; Gómez-Martín, Diana ; Vargas-Alarcón, Gilberto ; Posadas-Sánchez, Rosalinda ; Fragoso, José Manuel ; de la Peña, Aurora ; Rodríguez-Pérez, José Manuel ; Mata-Miranda, Mónica M ; Vázquez-Zapién, Gustavo J ; Martínez-Cuazitl, Adriana ; Martínez-Ruiz, Felipe de J ; Zayago-Angeles, Dulce M ; Ramos-Tavera, Luis ; Méndez-Aguilera, Alberto ; Camacho-Rea, María Del C ; Ordoñez-Sánchez, María L ; Segura-Kato, Yayoi ; Suarez-Ahedo, Carlos ; Olea-Torres, Jessel ; Herrera-López, Brígida ; Pineda, Carlos ; Martínez-Nava, Gabriela A ; López-Reyes, Alberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-5c683966a1eb16fc5c3a5cd0f1440b87a6f84df508c61470a065ce16474628563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>COVID-19</topic><topic>Immunology</topic><topic>Polymorphism</topic><topic>SARS-CoV-2</topic><topic>SERPINE1</topic><topic>TMPRSS2</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martínez-Gómez, Laura Edith</creatorcontrib><creatorcontrib>Martinez-Armenta, Carlos</creatorcontrib><creatorcontrib>Tusie-Luna, Teresa</creatorcontrib><creatorcontrib>Vázquez-Cárdenas, Paola</creatorcontrib><creatorcontrib>Vidal-Vázquez, Rosa P</creatorcontrib><creatorcontrib>Ramírez-Hinojosa, Juan P</creatorcontrib><creatorcontrib>Gómez-Martín, Diana</creatorcontrib><creatorcontrib>Vargas-Alarcón, Gilberto</creatorcontrib><creatorcontrib>Posadas-Sánchez, Rosalinda</creatorcontrib><creatorcontrib>Fragoso, José Manuel</creatorcontrib><creatorcontrib>de la Peña, Aurora</creatorcontrib><creatorcontrib>Rodríguez-Pérez, José Manuel</creatorcontrib><creatorcontrib>Mata-Miranda, Mónica M</creatorcontrib><creatorcontrib>Vázquez-Zapién, Gustavo J</creatorcontrib><creatorcontrib>Martínez-Cuazitl, Adriana</creatorcontrib><creatorcontrib>Martínez-Ruiz, Felipe de J</creatorcontrib><creatorcontrib>Zayago-Angeles, Dulce M</creatorcontrib><creatorcontrib>Ramos-Tavera, Luis</creatorcontrib><creatorcontrib>Méndez-Aguilera, Alberto</creatorcontrib><creatorcontrib>Camacho-Rea, María Del C</creatorcontrib><creatorcontrib>Ordoñez-Sánchez, María L</creatorcontrib><creatorcontrib>Segura-Kato, Yayoi</creatorcontrib><creatorcontrib>Suarez-Ahedo, Carlos</creatorcontrib><creatorcontrib>Olea-Torres, Jessel</creatorcontrib><creatorcontrib>Herrera-López, Brígida</creatorcontrib><creatorcontrib>Pineda, Carlos</creatorcontrib><creatorcontrib>Martínez-Nava, Gabriela A</creatorcontrib><creatorcontrib>López-Reyes, Alberto</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Frontiers in immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martínez-Gómez, Laura Edith</au><au>Martinez-Armenta, Carlos</au><au>Tusie-Luna, Teresa</au><au>Vázquez-Cárdenas, Paola</au><au>Vidal-Vázquez, Rosa P</au><au>Ramírez-Hinojosa, Juan P</au><au>Gómez-Martín, Diana</au><au>Vargas-Alarcón, Gilberto</au><au>Posadas-Sánchez, Rosalinda</au><au>Fragoso, José Manuel</au><au>de la Peña, Aurora</au><au>Rodríguez-Pérez, José Manuel</au><au>Mata-Miranda, Mónica M</au><au>Vázquez-Zapién, Gustavo J</au><au>Martínez-Cuazitl, Adriana</au><au>Martínez-Ruiz, Felipe de J</au><au>Zayago-Angeles, Dulce M</au><au>Ramos-Tavera, Luis</au><au>Méndez-Aguilera, Alberto</au><au>Camacho-Rea, María Del C</au><au>Ordoñez-Sánchez, María L</au><au>Segura-Kato, Yayoi</au><au>Suarez-Ahedo, Carlos</au><au>Olea-Torres, Jessel</au><au>Herrera-López, Brígida</au><au>Pineda, Carlos</au><au>Martínez-Nava, Gabriela A</au><au>López-Reyes, Alberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The fatal contribution of serine protease-related genetic variants to COVID-19 outcomes</atitle><jtitle>Frontiers in immunology</jtitle><addtitle>Front Immunol</addtitle><date>2024-03-27</date><risdate>2024</risdate><volume>15</volume><spage>1335963</spage><epage>1335963</epage><pages>1335963-1335963</pages><issn>1664-3224</issn><eissn>1664-3224</eissn><abstract>Serine proteases play a critical role during SARS-CoV-2 infection. Therefore, polymorphisms of transmembrane protease serine 2 (
) and serpine family E member 1 (
) could help to elucidate the contribution of variability to COVID-19 outcomes.
To evaluate the genetic variants of the genes previously associated with COVID-19 outcomes, we performed a cross-sectional study in which 1536 SARS-CoV-2-positive participants were enrolled.
(rs2070788, rs75603675, rs12329760) and
(rs2227631, rs2227667, rs2070682, rs2227692) were genotyped using the Open Array Platform. The association of polymorphisms with disease outcomes was determined by logistic regression analysis adjusted for covariates (age, sex, hypertension, type 2 diabetes, and obesity).
According to our codominant model, the GA genotype of rs2227667 (OR=0.55; 95% CI = 0.36-0.84;
=0.006) and the AG genotype of rs2227667 (OR=0.59; 95% CI = 0.38-0.91;
=0.02) of
played a protective role against disease. However, the rs2227692 T allele and TT genotype
(OR=1.45; 95% CI = 1.11-1.91;
=0.006; OR=2.08; 95% CI = 1.22-3.57;
=0.007; respectively) were associated with a decreased risk of death. Similarly, the rs75603675 AA genotype
had an OR of 1.97 (95% CI = 1.07-3.6;
=0.03) for deceased patients. Finally, the rs2227692 T allele
was associated with increased D-dimer levels (OR=1.24; 95% CI = 1.03-1.48;
=0.02).
Our data suggest that the rs75603675
and rs2227692
polymorphisms are associated with a poor outcome. Additionally, rs2227692
could participate in hypercoagulable conditions in critical COVID-19 patients, and this genetic variant could contribute to the identification of new pharmacological targets and treatment strategies to block the inhibition of TMPRSS2 entry into SARS-CoV-2.</abstract><cop>Switzerland</cop><pub>Frontiers Media S.A</pub><pmid>38601158</pmid><doi>10.3389/fimmu.2024.1335963</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1664-3224 |
ispartof | Frontiers in immunology, 2024-03, Vol.15, p.1335963-1335963 |
issn | 1664-3224 1664-3224 |
language | eng |
recordid | cdi_doaj_primary_oai_doaj_org_article_3e705dc06973479aaacfe27cf5f1e721 |
source | PubMed Central Free |
subjects | COVID-19 Immunology Polymorphism SARS-CoV-2 SERPINE1 TMPRSS2 |
title | The fatal contribution of serine protease-related genetic variants to COVID-19 outcomes |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T22%3A09%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20fatal%20contribution%20of%20serine%20protease-related%20genetic%20variants%20to%20COVID-19%20outcomes&rft.jtitle=Frontiers%20in%20immunology&rft.au=Mart%C3%ADnez-G%C3%B3mez,%20Laura%20Edith&rft.date=2024-03-27&rft.volume=15&rft.spage=1335963&rft.epage=1335963&rft.pages=1335963-1335963&rft.issn=1664-3224&rft.eissn=1664-3224&rft_id=info:doi/10.3389/fimmu.2024.1335963&rft_dat=%3Cproquest_doaj_%3E3037397756%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c420t-5c683966a1eb16fc5c3a5cd0f1440b87a6f84df508c61470a065ce16474628563%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3037397756&rft_id=info:pmid/38601158&rfr_iscdi=true |