Role of Oxidative Stress and Inflammation in Gestational Diabetes Mellitus

Gestational diabetes mellitus (GDM) is one of the most common pregnancy complications. It is related to several gestational and fetal adverse outcomes. Moreover, women with GDM and their infants have a high risk of developing type 2 diabetes in the future. The pathogenesis of GDM is not completely u...

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Bibliographic Details
Published in:Antioxidants 2023-09, Vol.12 (10), p.1812
Main Authors: Saucedo, Renata, Ortega-Camarillo, Clara, Ferreira-Hermosillo, Aldo, Díaz-Velázquez, Mary Flor, Meixueiro-Calderón, Claudia, Valencia-Ortega, Jorge
Format: Article
Language:English
Subjects:
Amino acids
Antioxidants
B cells
Biomarkers
Cell culture
Cell growth
Cytochrome
Cytokines
Development and progression
Diabetes in pregnancy
Diabetes mellitus (non-insulin dependent)
Dietary supplements
Fetuses
Free radicals
Gestational diabetes
Glucose
Homeostasis
Inflammation
Insulin resistance
Kinases
Lipids
Metabolic disorders
Mitochondria
NF-κB protein
Nitric oxide
Nitrogen dioxide
Oxidation
Oxidative stress
Pregnancy
Pregnancy complications
Pregnant women
Probiotics
Proteins
Protons
Reactive oxygen species
Review
Signal transduction
Type 2 diabetes
Uric acid
Womens health
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Summary:Gestational diabetes mellitus (GDM) is one of the most common pregnancy complications. It is related to several gestational and fetal adverse outcomes. Moreover, women with GDM and their infants have a high risk of developing type 2 diabetes in the future. The pathogenesis of GDM is not completely understood; nevertheless, two factors that contribute to its development are oxidative stress and inflammation. Oxidative stress and inflammation are related; reactive oxygen species (ROS) production can activate inflammatory cells and enhance the production of inflammatory mediators. Inflammation, in turn, leads to an increased ROS release, causing a vicious circle to ensue. Inflammatory responses can be achieved via the activation of the NF-κB signaling pathway. Herein, we review the English literature regarding oxidative stress and inflammation evaluated simultaneously in the same population, attempting to identify mechanisms through which these factors contribute to the development of GDM. Furthermore, the modulation of oxidative stress and inflammation by different therapies used in women with GDM and in cell models of GDM is included in the review. Probiotics and nutrient supplementations have been shown to reduce biomarkers of inflammation and oxidative stress in vitro and in women with GDM.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox12101812