Lipidomic analysis of plant-derived extracellular vesicles for guidance of potential anti-cancer therapy

Plant-derived extracellular vesicles (PEVs) have been regarded as a superior source for nanomedicine and drug delivery systems. Nevertheless, their clinical translation is hindered by the lack of clarity and even contradiction in their biomedical applications. Herein, we conducted a comprehensive co...

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Bibliographic Details
Published in:Bioactive materials 2025-04, Vol.46, p.82-96
Main Authors: Wang, Fei, Li, Lanya, Deng, Junyao, Ai, Jiacong, Mo, Shushan, Ding, Dandan, Xiao, Yingxian, Hu, Shiqi, Zhu, Dashuai, Li, Qishan, Zeng, Yan, Chen, Zhitong, Cheng, Ke, Li, Zhenhua
Format: Article
Language:English
Subjects:
anti-cancer therapy
Ginger
Lipidomic analysis
Plant-derived extracellular vesicles
Protein markers
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Summary:Plant-derived extracellular vesicles (PEVs) have been regarded as a superior source for nanomedicine and drug delivery systems. Nevertheless, their clinical translation is hindered by the lack of clarity and even contradiction in their biomedical applications. Herein, we conducted a comprehensive compositional analysis of four commonly used PEVs to fully understand their functional lipid contents and assess their potential therapeutic applications. The lipidomic analysis revealed the presence of cytotoxic gingerols and shogaols in ginger-derived EVs (GEVs). Subsequent in vitro and in vivo investigations substantiated the remarkable tumor cell inhibitory and tumor growth suppression efficacy of GEVs. The transcriptomic analysis indicated that GEVs regulate the cell cycle and p53 signaling pathways, thereby inducing cancer cell apoptosis. The supplementary proteomic analysis suggested the potential protein markers in PEV research. These findings highlight the value of multi-omics analyses in elucidating the potential therapeutic effects of PEVs and in advancing the development of PEV-based therapies. [Display omitted] •The comparative lipidomic analysis suggested the optimized application of GEVs in anti-cancer therapy.•Transcriptomic analysis showed that GEVs induced cancer cell apoptosis via regulating of cell cycle and p53 signaling pathways.•The proteomic analysis revealed three potential protein markers, which is beneficial for the quality control of PEVs.
ISSN:2452-199X
2452-199X
DOI:10.1016/j.bioactmat.2024.12.001