The Susceptibility of MDR-K. Pneumoniae to Polymyxin B Plus its Nebulised Form Versus Polymyxin B Alone in Critically Ill South Asian Patients

Critically ill patients in intensive care units are at high risk of dying not only from the severity of their illness but also from secondary causes such as hospital-acquired infections. USA national medical record-data show that approximately 10% of patients on mechanical ventilation in an intensiv...

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Bibliographic Details
Published in:Journal of critical care medicine (Universitatea de Medicină și Farmacie din Târgu-Mureș) 2021-01, Vol.7 (1), p.28-36
Main Authors: Hasan, Md. Jahidul, Rabbani, Raihan, Anam, Ahmad Mursel, Santini, Ario, Huq, Shihan Mahmud Redwanul
Format: Article
Language:English
Subjects:
MDR-KP
multi-drug resistant
multi-drug resistant k. pneumoniae (mdr-kp)
Polymyxin B
ventilator-associated pneumonia (VAP)
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Summary:Critically ill patients in intensive care units are at high risk of dying not only from the severity of their illness but also from secondary causes such as hospital-acquired infections. USA national medical record-data show that approximately 10% of patients on mechanical ventilation in an intensive care unit developed ventilator-associated pneumonia. Polymyxin B has been used intravenously in the treatment of multi-drug resistant gram-negative infections, either as a monotherapy or with other potentially effective antibiotics, and the recent international guidelines have emphasised the use of nebulised polymyxin B together with intravenous polymyxin B to gain the optimum clinical outcome in ventilator-associated pneumonia cases caused by multi-drug resistant gram-negative infections.
ISSN:2393-1817
2393-1809
2393-1817
DOI:10.2478/jccm-2020-0044