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Effects of MCF2L2, ADIPOQ and SOX2 genetic polymorphisms on the development of nephropathy in type 1 Diabetes Mellitus
MCF2L2, ADIPOQ and SOX2 genes are located in chromosome 3q26-27, which is linked to diabetic nephropathy (DN). ADIPOQ and SOX2 genetic polymorphisms are found to be associated with DN. In the present study, we first investigated the association between MCF2L2 and DN, and then evaluated effects of th...
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| Published in: | BMC medical genetics 2010-07, Vol.11 (1), p.116-116, Article 116 |
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| description | MCF2L2, ADIPOQ and SOX2 genes are located in chromosome 3q26-27, which is linked to diabetic nephropathy (DN). ADIPOQ and SOX2 genetic polymorphisms are found to be associated with DN. In the present study, we first investigated the association between MCF2L2 and DN, and then evaluated effects of these three genes on the development of DN.
A total of 1177 type 1 diabetes patients with and without DN from the GoKinD study were genotyped with TaqMan allelic discrimination. All subjects were of European descent.
Leu359Ile T/G variant in the MCF2L2 gene was found to be associated with DN in female subjects (P = 0.017, OR = 0.701, 95%CI 0.524-0.938) but not in males. The GG genotype carriers among female patients with DN had tendency decreased creatinine and cystatin levels compared to the carriers with either TT or TG genotypes. This polymorphism MCF2L2-rs7639705 together with SNPs of ADIPOQ-rs266729 and SOX2-rs11915160 had combined effects on decreased risk of DN in females (P = 0.001).
The present study provides evidence that MCF2L2, ADIPOQ and SOX2 genetic polymorphisms have effects on the resistance of DN in female T1D patients, and suggests that the linkage with DN in chromosome 3q may be explained by the cumulated genetic effects. |
| doi_str_mv | 10.1186/1471-2350-11-116 |
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A total of 1177 type 1 diabetes patients with and without DN from the GoKinD study were genotyped with TaqMan allelic discrimination. All subjects were of European descent.
Leu359Ile T/G variant in the MCF2L2 gene was found to be associated with DN in female subjects (P = 0.017, OR = 0.701, 95%CI 0.524-0.938) but not in males. The GG genotype carriers among female patients with DN had tendency decreased creatinine and cystatin levels compared to the carriers with either TT or TG genotypes. This polymorphism MCF2L2-rs7639705 together with SNPs of ADIPOQ-rs266729 and SOX2-rs11915160 had combined effects on decreased risk of DN in females (P = 0.001).
The present study provides evidence that MCF2L2, ADIPOQ and SOX2 genetic polymorphisms have effects on the resistance of DN in female T1D patients, and suggests that the linkage with DN in chromosome 3q may be explained by the cumulated genetic effects.</description><identifier>ISSN: 1471-2350</identifier><identifier>EISSN: 1471-2350</identifier><identifier>DOI: 10.1186/1471-2350-11-116</identifier><identifier>PMID: 20667095</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adiponectin - genetics ; Adult ; Alleles ; Chromosomes, Human, Pair 3 ; Complications and side effects ; Creatinine - metabolism ; Cystatins - metabolism ; Diabetes Mellitus, Type 1 - complications ; Diabetes Mellitus, Type 1 - genetics ; Diabetic nephropathies ; Diabetic Nephropathies - complications ; Diabetic Nephropathies - genetics ; Female ; Genetic aspects ; Genetic polymorphisms ; Genotype ; Guanine Nucleotide Exchange Factors - genetics ; Humans ; Kidney Failure, Chronic - complications ; Kidney Failure, Chronic - genetics ; Male ; Medicin och hälsovetenskap ; Middle Aged ; Phenotype ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic ; Rho Guanine Nucleotide Exchange Factors ; Risk factors ; SOXB1 Transcription Factors - genetics ; Type 1 diabetes</subject><ispartof>BMC medical genetics, 2010-07, Vol.11 (1), p.116-116, Article 116</ispartof><rights>COPYRIGHT 2010 BioMed Central Ltd.</rights><rights>Copyright ©2010 Zhang et al; licensee BioMed Central Ltd. 2010 Zhang et al; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b742t-40d1a2e2e5c52d6482c9ec94eb2b0135e19a4feb2bca3155bee05a8654541e0a3</citedby><cites>FETCH-LOGICAL-b742t-40d1a2e2e5c52d6482c9ec94eb2b0135e19a4feb2bca3155bee05a8654541e0a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919463/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919463/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,37013,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20667095$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:121460287$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Dongying</creatorcontrib><creatorcontrib>Efendic, Suad</creatorcontrib><creatorcontrib>Brismar, Kerstin</creatorcontrib><creatorcontrib>Gu, Harvest F</creatorcontrib><title>Effects of MCF2L2, ADIPOQ and SOX2 genetic polymorphisms on the development of nephropathy in type 1 Diabetes Mellitus</title><title>BMC medical genetics</title><addtitle>BMC Med Genet</addtitle><description>MCF2L2, ADIPOQ and SOX2 genes are located in chromosome 3q26-27, which is linked to diabetic nephropathy (DN). ADIPOQ and SOX2 genetic polymorphisms are found to be associated with DN. In the present study, we first investigated the association between MCF2L2 and DN, and then evaluated effects of these three genes on the development of DN.
A total of 1177 type 1 diabetes patients with and without DN from the GoKinD study were genotyped with TaqMan allelic discrimination. All subjects were of European descent.
Leu359Ile T/G variant in the MCF2L2 gene was found to be associated with DN in female subjects (P = 0.017, OR = 0.701, 95%CI 0.524-0.938) but not in males. The GG genotype carriers among female patients with DN had tendency decreased creatinine and cystatin levels compared to the carriers with either TT or TG genotypes. This polymorphism MCF2L2-rs7639705 together with SNPs of ADIPOQ-rs266729 and SOX2-rs11915160 had combined effects on decreased risk of DN in females (P = 0.001).
The present study provides evidence that MCF2L2, ADIPOQ and SOX2 genetic polymorphisms have effects on the resistance of DN in female T1D patients, and suggests that the linkage with DN in chromosome 3q may be explained by the cumulated genetic effects.</description><subject>Adiponectin - genetics</subject><subject>Adult</subject><subject>Alleles</subject><subject>Chromosomes, Human, Pair 3</subject><subject>Complications and side effects</subject><subject>Creatinine - metabolism</subject><subject>Cystatins - metabolism</subject><subject>Diabetes Mellitus, Type 1 - complications</subject><subject>Diabetes Mellitus, Type 1 - genetics</subject><subject>Diabetic nephropathies</subject><subject>Diabetic Nephropathies - complications</subject><subject>Diabetic Nephropathies - genetics</subject><subject>Female</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Genotype</subject><subject>Guanine Nucleotide Exchange Factors - genetics</subject><subject>Humans</subject><subject>Kidney Failure, Chronic - complications</subject><subject>Kidney Failure, Chronic - genetics</subject><subject>Male</subject><subject>Medicin och hälsovetenskap</subject><subject>Middle Aged</subject><subject>Phenotype</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Promoter Regions, Genetic</subject><subject>Rho Guanine Nucleotide Exchange Factors</subject><subject>Risk factors</subject><subject>SOXB1 Transcription Factors - genetics</subject><subject>Type 1 diabetes</subject><issn>1471-2350</issn><issn>1471-2350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNqFk12L1DAUhoso7rp675UEvBDBrvnsx40wzO7qwCyjroJ3IU1OZ7K2TW06o_PvTe04bGFFmtLm5H2f5JxDoug5weeEZMlbwlMSUyZwTEgYyYPo9Bh6eOf_JHri_S3GJM0YexydUJwkKc7FabS7LEvQvUeuRNfzK7qkb9DsYvFx9QmpxqCb1TeK1tBAbzVqXbWvXddurK-DoUH9BpCBHVSuraHpB0YD7aZzreo3e2SDYt8CIujCqgJ68Ogaqsr2W_80elSqysOzw_cs-np1-WX-IV6u3i_ms2VcpJz2MceGKAoUhBbUJDyjOgedcyhogQkTQHLFy2GmFSNCFABYqCwRXHACWLGzaDFyjVO3su1srbq9dMrKPwHXraXqQm4VSAZ5YdIcZ5pozopEca4wzwwuTABiE1j5yPI_od0WE1rbOSMP8e92eKUHSSjhCaZZGrzvRm8Q1GB0qFanqilistLYjVy7naQ5yXnCAmA-Agrr_gGYrmhXy6H_cui_JCSMJFBeHY7RuR9b8L2srdehJ6oBt_UyS1MRNqT5f5Upz3KWhvyC8uWoXKtQRduULuyvB7WcUcZxxrgYCnB-jyo8BmqrXQOlDfGJ4fXEEDQ9_OrXauu9XNx8nmrxqNWd876D8lgXMqSeJfdV4sXdhhwNf28G-w129AxD</recordid><startdate>20100728</startdate><enddate>20100728</enddate><creator>Zhang, Dongying</creator><creator>Efendic, Suad</creator><creator>Brismar, Kerstin</creator><creator>Gu, Harvest F</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><scope>DOA</scope></search><sort><creationdate>20100728</creationdate><title>Effects of MCF2L2, ADIPOQ and SOX2 genetic polymorphisms on the development of nephropathy in type 1 Diabetes Mellitus</title><author>Zhang, Dongying ; Efendic, Suad ; Brismar, Kerstin ; Gu, Harvest F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b742t-40d1a2e2e5c52d6482c9ec94eb2b0135e19a4feb2bca3155bee05a8654541e0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adiponectin - genetics</topic><topic>Adult</topic><topic>Alleles</topic><topic>Chromosomes, Human, Pair 3</topic><topic>Complications and side effects</topic><topic>Creatinine - metabolism</topic><topic>Cystatins - metabolism</topic><topic>Diabetes Mellitus, Type 1 - complications</topic><topic>Diabetes Mellitus, Type 1 - genetics</topic><topic>Diabetic nephropathies</topic><topic>Diabetic Nephropathies - complications</topic><topic>Diabetic Nephropathies - genetics</topic><topic>Female</topic><topic>Genetic aspects</topic><topic>Genetic polymorphisms</topic><topic>Genotype</topic><topic>Guanine Nucleotide Exchange Factors - genetics</topic><topic>Humans</topic><topic>Kidney Failure, Chronic - complications</topic><topic>Kidney Failure, Chronic - genetics</topic><topic>Male</topic><topic>Medicin och hälsovetenskap</topic><topic>Middle Aged</topic><topic>Phenotype</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Promoter Regions, Genetic</topic><topic>Rho Guanine Nucleotide Exchange Factors</topic><topic>Risk factors</topic><topic>SOXB1 Transcription Factors - genetics</topic><topic>Type 1 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Dongying</creatorcontrib><creatorcontrib>Efendic, Suad</creatorcontrib><creatorcontrib>Brismar, Kerstin</creatorcontrib><creatorcontrib>Gu, Harvest F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>BMC medical genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Dongying</au><au>Efendic, Suad</au><au>Brismar, Kerstin</au><au>Gu, Harvest F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of MCF2L2, ADIPOQ and SOX2 genetic polymorphisms on the development of nephropathy in type 1 Diabetes Mellitus</atitle><jtitle>BMC medical genetics</jtitle><addtitle>BMC Med Genet</addtitle><date>2010-07-28</date><risdate>2010</risdate><volume>11</volume><issue>1</issue><spage>116</spage><epage>116</epage><pages>116-116</pages><artnum>116</artnum><issn>1471-2350</issn><eissn>1471-2350</eissn><abstract>MCF2L2, ADIPOQ and SOX2 genes are located in chromosome 3q26-27, which is linked to diabetic nephropathy (DN). ADIPOQ and SOX2 genetic polymorphisms are found to be associated with DN. In the present study, we first investigated the association between MCF2L2 and DN, and then evaluated effects of these three genes on the development of DN.
A total of 1177 type 1 diabetes patients with and without DN from the GoKinD study were genotyped with TaqMan allelic discrimination. All subjects were of European descent.
Leu359Ile T/G variant in the MCF2L2 gene was found to be associated with DN in female subjects (P = 0.017, OR = 0.701, 95%CI 0.524-0.938) but not in males. The GG genotype carriers among female patients with DN had tendency decreased creatinine and cystatin levels compared to the carriers with either TT or TG genotypes. This polymorphism MCF2L2-rs7639705 together with SNPs of ADIPOQ-rs266729 and SOX2-rs11915160 had combined effects on decreased risk of DN in females (P = 0.001).
The present study provides evidence that MCF2L2, ADIPOQ and SOX2 genetic polymorphisms have effects on the resistance of DN in female T1D patients, and suggests that the linkage with DN in chromosome 3q may be explained by the cumulated genetic effects.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>20667095</pmid><doi>10.1186/1471-2350-11-116</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adiponectin - genetics Adult Alleles Chromosomes, Human, Pair 3 Complications and side effects Creatinine - metabolism Cystatins - metabolism Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - genetics Diabetic nephropathies Diabetic Nephropathies - complications Diabetic Nephropathies - genetics Female Genetic aspects Genetic polymorphisms Genotype Guanine Nucleotide Exchange Factors - genetics Humans Kidney Failure, Chronic - complications Kidney Failure, Chronic - genetics Male Medicin och hälsovetenskap Middle Aged Phenotype Polymorphism, Single Nucleotide Promoter Regions, Genetic Rho Guanine Nucleotide Exchange Factors Risk factors SOXB1 Transcription Factors - genetics Type 1 diabetes |
| title | Effects of MCF2L2, ADIPOQ and SOX2 genetic polymorphisms on the development of nephropathy in type 1 Diabetes Mellitus |
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