Methylmercury toxic mechanism related to protein degradation and chemokine transcription

Methylmercury is an environmental pollutant that causes neurotoxicity. Recent studies have reported that the ubiquitin-proteasome system is involved in defense against methylmercury toxicity through the degradation of proteins synthesizing the pyruvate. Mitochondrial accumulation of pyruvate can enh...

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Bibliographic Details
Published in:Environmental health and preventive medicine 2020-07, Vol.25 (1), p.1-5, Article 30
Main Authors: Lee, Jin-Yong, Hwang, Gi-Wook, Naganuma, Akira, Satoh, Masahiko
Format: Article
Language:English
Subjects:
Bioaccumulation
Biodegradation
Brain research
Chemokines
Dimethylmercury
Environmental health
Enzymes
Fetuses
Gene expression
Kidneys
Kinases
Mammals
Mercury (metal)
Metabolism
Metals
Methylmercury
Mitochondria
Molecular modelling
Nervous system
Neuroblastoma
Neurotoxicity
Poisoning
Pollutants
Proteasomes
Proteins
Pyruvate
Pyruvic acid
Review
Toxicity
Toxicology
Transcription
Ubiquitin
Ubiquitin-proteasome pathway
Yeast
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Summary:Methylmercury is an environmental pollutant that causes neurotoxicity. Recent studies have reported that the ubiquitin-proteasome system is involved in defense against methylmercury toxicity through the degradation of proteins synthesizing the pyruvate. Mitochondrial accumulation of pyruvate can enhance methylmercury toxicity. In addition, methylmercury exposure induces several immune-related chemokines, specifically in the brain, and may cause neurotoxicity. This summary highlights several molecular mechanisms of methylmercury-induced neurotoxicity.
ISSN:1342-078X
1347-4715
DOI:10.1186/s12199-020-00868-3