Coronary artery disease and the risk of life-threatening cardiac events after age 40 in long QT syndrome

Long QT syndrome (LQTS) and coronary artery disease (CAD) are both associated with increased risk of ventricular tachyarrhythmia However, there are limited data on the incremental risk conferred by CAD in adult patients with congenital LQTS. We aimed to investigate the risk associated with CAD and l...

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Bibliographic Details
Published in:Frontiers in cardiovascular medicine 2024-10, Vol.11, p.1418428
Main Authors: Barsheshet, Alon, Goldenberg, Ilan, Bjelic, Milica, Buturlin, Kirill, Erez, Aharon, Goldenberg, Gustavo, Chen, Anita Y, Polonsky, Bronislava, McNitt, Scott, Aktas, Mehmet, Zareba, Wojciech, Golovchiner, Gregory
Format: Article
Language:English
Subjects:
Cardiovascular Medicine
coronary artery disease
long QT syndrome
risk factors
sudden cardiac death
ventricular arrhythmia
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Summary:Long QT syndrome (LQTS) and coronary artery disease (CAD) are both associated with increased risk of ventricular tachyarrhythmia However, there are limited data on the incremental risk conferred by CAD in adult patients with congenital LQTS. We aimed to investigate the risk associated with CAD and life threatening events (LTEs) in patients with LQTS after age 40 years. The risk of LTEs (comprising aborted cardiac arrest, sudden cardiac death, or appropriate defibrillator shock) from age 40 through 75 years was examined in 1,020 subjects from the Rochester LQTS registry, categorized to CAD (  = 137) or no-CAD (  = 883) subgroups. Survival analysis showed that patients with CAD had a significantly higher cumulative event rate of LTEs from 40 to 75 years (35%) compared with those without CAD (7%;  4-fold (  = 0.008) increased risk of LTEs among LQTS patients with a lower-range QTc (
ISSN:2297-055X
2297-055X
DOI:10.3389/fcvm.2024.1418428