Individual and combined contributions of non-high-density lipoprotein cholesterol and brachial-ankle pulse wave velocity to cardiovascular disease risk: Results of a prospective study using the Kailuan cohort

• Published in: Frontiers in cardiovascular medicine 2023-02, Vol.10, p.1105464-1105464
• Main Authors: Zheng, Qiongbing, Wang, Hui, Wang, Xianxuan, Lan, Youmian, Wu, Weiqiang, Yu, Xinran, Huang, Zegui, Chen, Zekai, Cai, Zefeng, Lin, Qi, Zhou, Houshi, Zhu, Yongdong, Liu, Muyuan, Wu, Kuangyi, Zheng, Huancong, Wu, Shouling, Chen, Youren
• Format: Article
• Language: English
• Subjects: brachial-ankle pulse wave velocity; cardiovascular diseases; Cardiovascular Medicine; combined effect; Kailuan cohort; non-high-density lipoprotein cholesterol
• ISSN: 2297-055X; 2297-055X
• DOI: 10.3389/fcvm.2023.1105464

We aimed to characterize the relationship of a combination of circulating non-high-density lipoprotein-cholesterol (non-HDL-C) concentration and brachial-ankle pulse wave velocity (baPWV) with cardiovascular disease (CVD). We performed a prospective cohort study of the residents of the Kailuan community, with data from a total of 45,051 participants being included in the final analysis. The participants were allocated to four groups according to their non-HDL-C and baPWV status, each of which was categorized as high or normal. Cox proportional hazards models were used to explore the relationships of non-HDL-C and baPWV, individually and in combination, with the incidence of CVD. During the 5.04-year follow-up period, 830 participants developed CVD. Compared with the Normal non-HDL-C group independently, the multivariable adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for CVD in the High non-HDL-C was 1.25 (1.08-1.46). Compared with the Normal baPWV group independently, the HRs and 95% CIs for CVD in the High baPWV was 1.51 (1.29-1.76). In addition, compared with the Normal both non-HDL-C and baPWV group, the HRs and 95% CIs for CVD in the High non-HDL-C and normal baPWV, Normal non-HDL-C and high baPWV, and High both non-HDL-C and baPWV groups were 1.40 (1.07-1.82), 1.56 (1.30-1.88), and 1.89 (1.53-2.35), respectively. High non-HDL-C concentration and high baPWV are independently associated with a higher risk of CVD, and individuals with high both non-HDL-C and baPWV are at a still higher risk of CVD.