In Vitro Determination of the Main Effects in the Design of High-Flow Nasal Therapy Systems with Respect to Aerosol Performance

Introduction The use of concurrent aerosol delivery during high-flow nasal therapy (HFNT) may be exploited to facilitate the delivery of a variety of prescribed medications for inhalation. Until now, a systematic approach to determine the conditions required to yield an optimal emitted dose has not...

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Bibliographic Details
Published in:Pulmonary therapy 2018-06, Vol.4 (1), p.73-86
Main Authors: Bennett, Gavin, Joyce, Mary, Sweeney, Louise, MacLoughlin, Ronan
Format: Article
Language:English
Subjects:
Aerosol
Design of experiments
Droplet size
Emitted dose
Family Medicine
Flow rate
Gas flow
General Practice
High-flow nasal therapy
Internal Medicine
Medicine & Public Health
Original Research
Pharmacoeconomics and Health Outcomes
Pharmacotherapy
Pneumology/Respiratory System
Quality of Life Research
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Summary:Introduction The use of concurrent aerosol delivery during high-flow nasal therapy (HFNT) may be exploited to facilitate the delivery of a variety of prescribed medications for inhalation. Until now, a systematic approach to determine the conditions required to yield an optimal emitted dose has not been reported. The aim of this study was to establish the effects of gas flow rate, input droplet size, and nebulizer position on the amount of aerosol exiting the nasal cannula during HFNT and thus becoming available for inhalation. Methods Testing was completed according to a factorial statistical design of experiments (DOE) approach. Emitted dose was characterized with a vibrating mesh nebulizer (Aerogen Solo, Aerogen Ltd) for an adult model of HFNT at three clinically relevant gas flow rates, using three nebulizers producing varying input droplet sizes and placed at two different nebulizer positions. Results Increasing the gas flow rate significantly lowered the emitted dose, with a dose of 7.10% obtained at 10 LPM, 2.67% at 25 LPM, and 1.30% at 40 LPM ( p
ISSN:2364-1754
2364-1746
DOI:10.1007/s41030-018-0054-x