A laboratory-based beam tracking x-ray imaging method achieving two-dimensional phase sensitivity and isotropic resolution with unidirectional undersampling

Beam tracking X-ray Phase Contrast Imaging is a “Shack-Hartmann” type approach which uses a pre-sample mask to split the x-rays into “beamlets” which are interrogated by a detector with sufficient resolution. The ultimate spatial resolution is determined by the size of the mask apertures, however ac...

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Bibliographic Details
Published in:Scientific reports 2023-05, Vol.13 (1), p.8707-8707, Article 8707
Main Authors: Lioliou, G., Navarrete-León, C., Astolfo, A., Savvidis, S., Bate, D., Endrizzi, M., Hagen, C. K., Olivo, A.
Format: Article
Language:English
Subjects:
639/166/985
639/766/400/1106
639/766/930/2735
Humanities and Social Sciences
multidisciplinary
Science
Science (multidisciplinary)
Spatial discrimination
X-rays
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Summary:Beam tracking X-ray Phase Contrast Imaging is a “Shack-Hartmann” type approach which uses a pre-sample mask to split the x-rays into “beamlets” which are interrogated by a detector with sufficient resolution. The ultimate spatial resolution is determined by the size of the mask apertures, however achieving this resolution level requires “stepping” the sample or the mask in increments equal to the aperture size (“dithering”). If an array of circular apertures is used (which also provides two-dimensional phase sensitivity) instead of long parallel slits, this stepping needs to be carried out in two directions, which lengthens scan times significantly. We present a mask design obtained by offsetting rows of circular apertures, allowing for two-dimensional sensitivity and isotropic resolution while requiring sample or mask stepping in one direction only. We present images of custom-built phantoms and biological specimens, demonstrating that quantitative phase retrieval and near aperture-limited spatial resolutions are obtained in two orthogonal directions.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-35901-2