Mesenchymal Stem Cell Therapy in Alopecia Areata: Visual and Molecular Evidence from a Mouse Model

Recent studies have highlighted the potential of Mesenchymal Stem Cells (MSCs) as an alternative treatment for Alopecia Areata (AA) due to their immunosuppressive properties. While MSCs have shown promise in cell experiments, their effectiveness in vivo remains uncertain. This study aims to validate...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-09, Vol.25 (17), p.9236
Main Authors: Park, Song-Hee, Song, Seo-Won, Lee, Yu-Jin, Kang, Hoon, Kim, Jung-Eun
Format: Article
Language:English
Subjects:
Alopecia
alopecia areata
Alopecia Areata - metabolism
Alopecia Areata - therapy
Animal research
Animals
Autoimmune diseases
Baldness
beta Catenin - genetics
beta Catenin - metabolism
Cytokines - metabolism
Cytotoxicity
Disease
Disease Models, Animal
Female
Follicles
Gene expression
Hair loss
immunosuppressive
in vivo
Interferon-gamma - metabolism
Kinases
local
Lymphoid Enhancer-Binding Factor 1 - genetics
Lymphoid Enhancer-Binding Factor 1 - metabolism
Mesenchymal Stem Cell Transplantation - methods
mesenchymal stem cells
Mesenchymal Stem Cells - cytology
Mesenchymal Stem Cells - metabolism
Mice
Skin
Stem cells
systemic
Wnt Signaling Pathway
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Summary:Recent studies have highlighted the potential of Mesenchymal Stem Cells (MSCs) as an alternative treatment for Alopecia Areata (AA) due to their immunosuppressive properties. While MSCs have shown promise in cell experiments, their effectiveness in vivo remains uncertain. This study aims to validate local administration of MSC therapy's efficacy in AA treatment through animal experiments. AA was induced through Interferon-gamma (IFN-γ) administration in mice, and MSC treatment (MSCT)'s effects were assessed visually and through tissue analysis. The MSC-treated group showed more hair regrowth compared to the control (CTL) group. MSCT notably reduced local inflammatory cytokines (JAK1, JAK2, STAT1, STAT3, IFN-γR, IL-1β, IL-16, IL-17α, and IL-18) in AA-induced mice's skin, but systemic cytokine levels remained unchanged. Furthermore, MSC treatment normalized the expression of Wnt/β-catenin signaling pathway genes (LEF1 and β-catenin) and growth factors (FGF7 and FGF2), which are crucial for hair cycle regulation. This study lays the groundwork for further exploring MSCs as a potential treatment for AA, but more research is needed to fully understand their therapeutic potential.
ISSN:1661-6596
1422-0067
1422-0067
DOI:10.3390/ijms25179236