Bioactive extracts from the industrial byproduct of passion fruit promote better glycemic control in an adjuvant treatment with insulin and prevent kidney and heart damage in rats with type 1 Diabetes mellitus

The study investigated the potential benefits of passion fruit peel extracts (PFAE and PFHE), derived from Passiflora edulis fo. flavicarpa, for Type 1 Diabetes mellitus (T1DM). Extracts were produced using eco-friendly solvents and evaluated in a T1DM chronic model. Acute toxicity tests showed the...

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Bibliographic Details
Published in:Journal of functional foods 2025-01, Vol.124, p.106638, Article 106638
Main Authors: Cabral, Bárbara, Galdino, Ony Araújo, de Souza Gomes, Iago, Alves, Jovelina Samara Ferreira, Marques, José Ivan, Souza, Karla Simone Costa de, da Silva, Rodrigo Moreira, Abreu, Bento João, Lopes, Norberto Peporine, Zucolotto, Silvana Maria, Rezende, Adriana Augusto de
Format: Article
Language:English
Subjects:
Antidiabetic agents
Flavonoids
Fruit peel
Passiflora edulis
Safety
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Summary:The study investigated the potential benefits of passion fruit peel extracts (PFAE and PFHE), derived from Passiflora edulis fo. flavicarpa, for Type 1 Diabetes mellitus (T1DM). Extracts were produced using eco-friendly solvents and evaluated in a T1DM chronic model. Acute toxicity tests showed the extracts (2000 mg/kg, orally) were safe. Liquid chromatography coupled to triple quadrupole mass spectrometry (LC-QqQ-MS/MS) identified five C-glycosylated flavonoids (vicenin-2, orientin, isoorientin, vitexin, isovitexin) in the extracts. Adjuvant treatment with extracts alongside insulin significantly improved glycemic control over 60 days compared to insulin alone (p 
ISSN:1756-4646
DOI:10.1016/j.jff.2024.106638