The corneal effects of intravitreal dexamethasone implantation

Objectives: To evaluate the corneal effects of the intravitreal dexamethasone implantation using corneal topography and specular microscopy. Material and methods: 27 eyes of the 27 patients who received a single intravitreal dexamethasone implantation dose for diabetic macular edema were enrolled in...

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Bibliographic Details
Published in:Therapeutic advances in ophthalmology 2020-01, Vol.12, p.2515841420947544-2515841420947544
Main Authors: Bayat, Alper Halil, Karataş, Gamze, Kurt, Muhammet Mustafa, Elçioğlu, Mustafa Nuri
Format: Article
Language:English
Subjects:
Cornea
Original Research
Steroids
Topography
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Summary:Objectives: To evaluate the corneal effects of the intravitreal dexamethasone implantation using corneal topography and specular microscopy. Material and methods: 27 eyes of the 27 patients who received a single intravitreal dexamethasone implantation dose for diabetic macular edema were enrolled in this study. Sirius topography and EM-3000 specular microscopic examinations were performed at the initial examination (baseline), and then on the first day, during the first week, and 1 month after IDI. Changes in corneal parameters were investigated. Results: The mean age was 58.66 ± 6.59 years. 15 patients were men, and 12 were women. The mean disease duration was 12.2 ± 2.4 months, and mean glycosylated hemoglobin (HbA1c) was 7.2 ± 1.1. After dexamethasone injection, the mean central corneal thickness, endothelial cell density, and coefficient variation of cell area presented a statistically significant decrease (p  0.05). Conclusion: Intravitreal dexamethasone implantation affects corneal endothelial cell structure but does not appear to affect corneal topography parameters.
ISSN:2515-8414
2515-8414
DOI:10.1177/2515841420947544