Apoptosis through Death Receptors in Temporal Lobe Epilepsy-Associated Hippocampal Sclerosis

Seizure models have demonstrated that neuroinflammation and neurodegeneration are preponderant characteristics of epilepsy. Considering the lack of clinical studies, our aim is to investigate the extrinsic pathway of apoptosis in pharmacoresistant temporal lobe epilepsy (TLE) associated with hippoca...

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Bibliographic Details
Published in:Mediators of inflammation 2016-01, Vol.2016 (2016), p.1-12
Main Authors: Teocchi, Marcelo Ananias, D’Souza-Li, Lília
Format: Article
Language:English
Subjects:
Adolescent
Adult
Analysis
Apoptosis
Apoptosis - genetics
Apoptosis - physiology
Epilepsy
Epilepsy, Temporal Lobe - genetics
Epilepsy, Temporal Lobe - metabolism
Female
Hippocampus - metabolism
Humans
In Vitro Techniques
Investigations
Kinases
Male
Physiological aspects
Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics
Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism
Receptors, Tumor Necrosis Factor, Type I - genetics
Receptors, Tumor Necrosis Factor, Type I - metabolism
Receptors, Tumor Necrosis Factor, Type II - genetics
Receptors, Tumor Necrosis Factor, Type II - metabolism
Sclerosis - genetics
Sclerosis - metabolism
Seizures (Medicine)
Tumor necrosis factor-TNF
Young Adult
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Summary:Seizure models have demonstrated that neuroinflammation and neurodegeneration are preponderant characteristics of epilepsy. Considering the lack of clinical studies, our aim is to investigate the extrinsic pathway of apoptosis in pharmacoresistant temporal lobe epilepsy (TLE) associated with hippocampal sclerosis (HS) patients, TLE(HS). By a specific death receptor-mediated apoptosis array plate, 31 upregulated targets were revealed in the sclerotic hippocampus from TLE(HS) patients. Amongst them are the encoding genes for ligands (FASLG, TNF, and TNFSF10) and death receptors (FAS, TNFRSF1A, TNFRSF10A, and TNFRSF10B). In addition, we evaluated the hippocampal relative mRNA expression of the two TNF receptors, TNFRSF1A and TNFRSF1B, in patients, being both upregulated (n=14; P
ISSN:0962-9351
1466-1861
DOI:10.1155/2016/8290562