Optimization of Printing Parameters for Digital Light Processing 3D Printing of Hollow Microneedle Arrays

3D printing is an emerging technology aiming towards personalized drug delivery, among many other applications. Microneedles (MN) are a viable method for transdermal drug delivery that is becoming more popular for delivery through the skin. However, there is a need for a faster fabrication process w...

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Bibliographic Details
Published in:Pharmaceutics 2021-11, Vol.13 (11), p.1837
Main Authors: Mathew, Essyrose, Pitzanti, Giulia, Gomes Dos Santos, Ana L, Lamprou, Dimitrios A
Format: Article
Language:English
Subjects:
3-D printers
3D printing
additive manufacturing
Arrays
CAD
Computer aided design
digital light processing
Drugs
emerging technologies
hollow microneedles
Pathogens
Skin
Software
transdermal drug delivery
Transdermal medication
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Summary:3D printing is an emerging technology aiming towards personalized drug delivery, among many other applications. Microneedles (MN) are a viable method for transdermal drug delivery that is becoming more popular for delivery through the skin. However, there is a need for a faster fabrication process with potential for easily exploring different geometries of MNs. In the current study, a digital light processing (DLP) method of 3D printing for fabrication of hollow MN arrays using commercial UV curable resin was proposed. Print quality was optimised by assessing the effect of print angle on needle geometries. Mechanical testing of MN arrays was conducted using a texture analyser. Angled prints were found to produce prints with geometries closer to the CAD designs. Curing times were found to affect the mechanical strength of MNs, with arrays not breaking when subjected to 300 N of force but were bent. Overall, DLP process produced hollow MNs with good mechanical strength and depicts a viable, quick, and efficient method for the fabrication of hollow MN arrays.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics13111837