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Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human

In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus genus which also includes the related...

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Published in:Retrovirology 2007-03, Vol.4 (1), p.18-18, Article 18
Main Authors: Gillet, Nicolas, Florins, Arnaud, Boxus, Mathieu, Burteau, Catherine, Nigro, Annamaria, Vandermeers, Fabian, Balon, Hervé, Bouzar, Amel-Baya, Defoiche, Julien, Burny, Arsène, Reichert, Michal, Kettmann, Richard, Willems, Luc
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creator Gillet, Nicolas
Florins, Arnaud
Boxus, Mathieu
Burteau, Catherine
Nigro, Annamaria
Vandermeers, Fabian
Balon, Hervé
Bouzar, Amel-Baya
Defoiche, Julien
Burny, Arsène
Reichert, Michal
Kettmann, Richard
Willems, Luc
description In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus genus which also includes the related human T-lymphotropic virus type 1 (HTLV-1). This review summarizes current knowledge of this viral system, which is important as a model for leukemogenesis. Recently, the BLV model has also cast light onto novel prospects for therapies of HTLV induced diseases, for which no satisfactory treatment exists so far.
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subjects Animals
Anti-Retroviral Agents - pharmacology
Anti-Retroviral Agents - therapeutic use
Anti-Retroviral Agents/pharmacology/therapeutic use
B-Lymphocytes - pathology
B-Lymphocytes - physiology
B-Lymphocytes - virology
B-Lymphocytes/pathology/physiology/virology
Bovine leukemia virus
Cattle
Cytokines - metabolism
Disease Models, Animal
Enzootic Bovine Leukosis - drug therapy
Enzootic Bovine Leukosis - physiopathology
Enzootic Bovine Leukosis - virology
Enzootic Bovine Leukosis/drug therapy/physiopathology/virology
Human T-lymphotropic virus
Human T-lymphotropic virus 1
Human T-lymphotropic virus 1 - pathogenicity
Humans
Leukemia Virus, Bovine - genetics
Leukemia Virus, Bovine - metabolism
Leukemia Virus, Bovine - pathogenicity
Leukemia Virus, Bovine/genetics/metabolism/pathogenicity
Leukemia-Lymphoma, Adult T-Cell - drug therapy
Leukemia-Lymphoma, Adult T-Cell - physiopathology
Leukemia-Lymphoma, Adult T-Cell/drug therapy/physiopathology
Leukocytes, Mononuclear - pathology
Leukocytes, Mononuclear - physiology
Leukocytes, Mononuclear - virology
Leukocytes, Mononuclear/pathology/physiology/virology
Life sciences
Médecine vétérinaire & santé animale
Review
Sciences du vivant
Sheep
Sheep Diseases - drug therapy
Sheep Diseases - immunology
Sheep Diseases - physiopathology
Sheep Diseases - virology
Sheep Diseases/drug therapy/immunology/physiopathology/virology
Veterinary medicine & animal health
Viral Proteins - genetics
Viral Proteins - metabolism
Viral Proteins/genetics/metabolism
title Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human
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