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Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human
In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus genus which also includes the related...
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Published in: | Retrovirology 2007-03, Vol.4 (1), p.18-18, Article 18 |
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creator | Gillet, Nicolas Florins, Arnaud Boxus, Mathieu Burteau, Catherine Nigro, Annamaria Vandermeers, Fabian Balon, Hervé Bouzar, Amel-Baya Defoiche, Julien Burny, Arsène Reichert, Michal Kettmann, Richard Willems, Luc |
description | In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus genus which also includes the related human T-lymphotropic virus type 1 (HTLV-1). This review summarizes current knowledge of this viral system, which is important as a model for leukemogenesis. Recently, the BLV model has also cast light onto novel prospects for therapies of HTLV induced diseases, for which no satisfactory treatment exists so far. |
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The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus genus which also includes the related human T-lymphotropic virus type 1 (HTLV-1). This review summarizes current knowledge of this viral system, which is important as a model for leukemogenesis. Recently, the BLV model has also cast light onto novel prospects for therapies of HTLV induced diseases, for which no satisfactory treatment exists so far.</description><identifier>ISSN: 1742-4690</identifier><identifier>EISSN: 1742-4690</identifier><identifier>DOI: 10.1186/1742-4690-4-18</identifier><identifier>PMID: 17362524</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Animals ; Anti-Retroviral Agents - pharmacology ; Anti-Retroviral Agents - therapeutic use ; Anti-Retroviral Agents/pharmacology/therapeutic use ; B-Lymphocytes - pathology ; B-Lymphocytes - physiology ; B-Lymphocytes - virology ; B-Lymphocytes/pathology/physiology/virology ; Bovine leukemia virus ; Cattle ; Cytokines - metabolism ; Disease Models, Animal ; Enzootic Bovine Leukosis - drug therapy ; Enzootic Bovine Leukosis - physiopathology ; Enzootic Bovine Leukosis - virology ; Enzootic Bovine Leukosis/drug therapy/physiopathology/virology ; Human T-lymphotropic virus ; Human T-lymphotropic virus 1 ; Human T-lymphotropic virus 1 - pathogenicity ; Humans ; Leukemia Virus, Bovine - genetics ; Leukemia Virus, Bovine - metabolism ; Leukemia Virus, Bovine - pathogenicity ; Leukemia Virus, Bovine/genetics/metabolism/pathogenicity ; Leukemia-Lymphoma, Adult T-Cell - drug therapy ; Leukemia-Lymphoma, Adult T-Cell - physiopathology ; Leukemia-Lymphoma, Adult T-Cell/drug therapy/physiopathology ; Leukocytes, Mononuclear - pathology ; Leukocytes, Mononuclear - physiology ; Leukocytes, Mononuclear - virology ; Leukocytes, Mononuclear/pathology/physiology/virology ; Life sciences ; Médecine vétérinaire & santé animale ; Review ; Sciences du vivant ; Sheep ; Sheep Diseases - drug therapy ; Sheep Diseases - immunology ; Sheep Diseases - physiopathology ; Sheep Diseases - virology ; Sheep Diseases/drug therapy/immunology/physiopathology/virology ; Veterinary medicine & animal health ; Viral Proteins - genetics ; Viral Proteins - metabolism ; Viral Proteins/genetics/metabolism</subject><ispartof>Retrovirology, 2007-03, Vol.4 (1), p.18-18, Article 18</ispartof><rights>Copyright © 2007 Gillet et al; licensee BioMed Central Ltd. 2007 Gillet et al; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b652t-f6271e6f66a5c7749e07890cb4dedd6b0816803e8a002fd02c09b00b5deff1373</citedby><cites>FETCH-LOGICAL-b652t-f6271e6f66a5c7749e07890cb4dedd6b0816803e8a002fd02c09b00b5deff1373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1839114/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1839114/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17362524$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gillet, Nicolas</creatorcontrib><creatorcontrib>Florins, Arnaud</creatorcontrib><creatorcontrib>Boxus, Mathieu</creatorcontrib><creatorcontrib>Burteau, Catherine</creatorcontrib><creatorcontrib>Nigro, Annamaria</creatorcontrib><creatorcontrib>Vandermeers, Fabian</creatorcontrib><creatorcontrib>Balon, Hervé</creatorcontrib><creatorcontrib>Bouzar, Amel-Baya</creatorcontrib><creatorcontrib>Defoiche, Julien</creatorcontrib><creatorcontrib>Burny, Arsène</creatorcontrib><creatorcontrib>Reichert, Michal</creatorcontrib><creatorcontrib>Kettmann, Richard</creatorcontrib><creatorcontrib>Willems, Luc</creatorcontrib><title>Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human</title><title>Retrovirology</title><addtitle>Retrovirology</addtitle><description>In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus genus which also includes the related human T-lymphotropic virus type 1 (HTLV-1). This review summarizes current knowledge of this viral system, which is important as a model for leukemogenesis. Recently, the BLV model has also cast light onto novel prospects for therapies of HTLV induced diseases, for which no satisfactory treatment exists so far.</description><subject>Animals</subject><subject>Anti-Retroviral Agents - pharmacology</subject><subject>Anti-Retroviral Agents - therapeutic use</subject><subject>Anti-Retroviral Agents/pharmacology/therapeutic use</subject><subject>B-Lymphocytes - pathology</subject><subject>B-Lymphocytes - physiology</subject><subject>B-Lymphocytes - virology</subject><subject>B-Lymphocytes/pathology/physiology/virology</subject><subject>Bovine leukemia virus</subject><subject>Cattle</subject><subject>Cytokines - metabolism</subject><subject>Disease Models, Animal</subject><subject>Enzootic Bovine Leukosis - drug therapy</subject><subject>Enzootic Bovine Leukosis - physiopathology</subject><subject>Enzootic Bovine Leukosis - virology</subject><subject>Enzootic Bovine Leukosis/drug therapy/physiopathology/virology</subject><subject>Human T-lymphotropic virus</subject><subject>Human T-lymphotropic virus 1</subject><subject>Human T-lymphotropic virus 1 - 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physiopathology</subject><subject>Sheep Diseases - virology</subject><subject>Sheep Diseases/drug therapy/immunology/physiopathology/virology</subject><subject>Veterinary medicine & animal health</subject><subject>Viral Proteins - genetics</subject><subject>Viral Proteins - metabolism</subject><subject>Viral Proteins/genetics/metabolism</subject><issn>1742-4690</issn><issn>1742-4690</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNqFkk1v1DAQhi0EomXhyhH5xC1lbCe2wwGpqvioVMQFzpbtjHddknixk5X678l-qLRCiJNHnneeee0ZQl4zuGBMy3dM1byqZQtVXTH9hJzfXzx9EJ-RF6XcAgimQT8nZ0wJyRten5P5K_qNHWMZCk2B9jj_xCGtccQSC41jN3vsqLujLu3iiCdBtHQX81ze021OZYt-KjSkTMe0w57acYpVxikvJdn2dNpgttuIex7dzIMdX5JnwfYFX53OFfnx6eP3qy_VzbfP11eXN5WTDZ-qILliKIOUtvFK1S2C0i14V3fYddKBZlKDQG0BeOiAe2gdgGs6DIEJJVbk-sjtkr012xwHm-9MstEcLlJeG5un6Hs0IkBolQJpUdbM-pY1jZCt63QrIRxYH46s7ewG7DyO0_K4R9DHmTFuzDrtDNOiZaxeAPwI6COucWnuotnxQ-EhnvvFjTcODedSGwbN4mBFLo9FLqZ_dH2c8Wkw-7mb_dxNve--Im9PznP6NWOZzBCLx763I6a5GAWC1w1X_xVyYGJZHb4IL45Cv4y_ZAz3hhiY_V7-beHNw8_7Iz8tovgNqovgeA</recordid><startdate>20070316</startdate><enddate>20070316</enddate><creator>Gillet, Nicolas</creator><creator>Florins, Arnaud</creator><creator>Boxus, Mathieu</creator><creator>Burteau, Catherine</creator><creator>Nigro, Annamaria</creator><creator>Vandermeers, Fabian</creator><creator>Balon, Hervé</creator><creator>Bouzar, Amel-Baya</creator><creator>Defoiche, Julien</creator><creator>Burny, Arsène</creator><creator>Reichert, Michal</creator><creator>Kettmann, Richard</creator><creator>Willems, Luc</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><scope>Q33</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20070316</creationdate><title>Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human</title><author>Gillet, Nicolas ; Florins, Arnaud ; Boxus, Mathieu ; Burteau, Catherine ; Nigro, Annamaria ; Vandermeers, Fabian ; Balon, Hervé ; Bouzar, Amel-Baya ; Defoiche, Julien ; Burny, Arsène ; Reichert, Michal ; Kettmann, Richard ; Willems, Luc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b652t-f6271e6f66a5c7749e07890cb4dedd6b0816803e8a002fd02c09b00b5deff1373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Anti-Retroviral Agents - 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The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus genus which also includes the related human T-lymphotropic virus type 1 (HTLV-1). This review summarizes current knowledge of this viral system, which is important as a model for leukemogenesis. Recently, the BLV model has also cast light onto novel prospects for therapies of HTLV induced diseases, for which no satisfactory treatment exists so far.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>17362524</pmid><doi>10.1186/1742-4690-4-18</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Animals Anti-Retroviral Agents - pharmacology Anti-Retroviral Agents - therapeutic use Anti-Retroviral Agents/pharmacology/therapeutic use B-Lymphocytes - pathology B-Lymphocytes - physiology B-Lymphocytes - virology B-Lymphocytes/pathology/physiology/virology Bovine leukemia virus Cattle Cytokines - metabolism Disease Models, Animal Enzootic Bovine Leukosis - drug therapy Enzootic Bovine Leukosis - physiopathology Enzootic Bovine Leukosis - virology Enzootic Bovine Leukosis/drug therapy/physiopathology/virology Human T-lymphotropic virus Human T-lymphotropic virus 1 Human T-lymphotropic virus 1 - pathogenicity Humans Leukemia Virus, Bovine - genetics Leukemia Virus, Bovine - metabolism Leukemia Virus, Bovine - pathogenicity Leukemia Virus, Bovine/genetics/metabolism/pathogenicity Leukemia-Lymphoma, Adult T-Cell - drug therapy Leukemia-Lymphoma, Adult T-Cell - physiopathology Leukemia-Lymphoma, Adult T-Cell/drug therapy/physiopathology Leukocytes, Mononuclear - pathology Leukocytes, Mononuclear - physiology Leukocytes, Mononuclear - virology Leukocytes, Mononuclear/pathology/physiology/virology Life sciences Médecine vétérinaire & santé animale Review Sciences du vivant Sheep Sheep Diseases - drug therapy Sheep Diseases - immunology Sheep Diseases - physiopathology Sheep Diseases - virology Sheep Diseases/drug therapy/immunology/physiopathology/virology Veterinary medicine & animal health Viral Proteins - genetics Viral Proteins - metabolism Viral Proteins/genetics/metabolism |
title | Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human |
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