Protective Effect of Shexiang Baoxin Pill on Myocardial Ischemia/Reperfusion Injury in Patients With STEMI

Background: There is no definite effect in the treatment of myocardial ischemia/reperfusion (I/R) injury in patients with acute ST-segment elevation myocardial infarction (STEMI). We evaluated the protective effect of Shexiang Baoxin Pill (SBP) on I/R injury in STEMI patients. Methods: STEMI patient...

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Bibliographic Details
Published in:Frontiers in pharmacology 2021-09, Vol.12, p.721011-721011
Main Authors: Qin, Haixia, Li, Siyuan, Liu, Zhenbing
Format: Article
Language:English
Subjects:
myocardial ischemia reperfusion injury
myocardial protection
myocardial salvage
Pharmacology
shexiang baoxin pill
ST-segment elevation myocardial infarction
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Summary:Background: There is no definite effect in the treatment of myocardial ischemia/reperfusion (I/R) injury in patients with acute ST-segment elevation myocardial infarction (STEMI). We evaluated the protective effect of Shexiang Baoxin Pill (SBP) on I/R injury in STEMI patients. Methods: STEMI patients were randomly divided into a primary percutaneous coronary intervention (PPCI) group (n = 52) and a PPCI + SBP group (n = 51). The area at risk of infarction (AAR) and final infarct size (FIS) were examined by single-photon emission computed tomography (SPECT). I/R injury was assessed using myocardial salvage (MS) and salvage index (SI) calculated from AAR and FIS. Results: The ST-segment resolution (STR) in the PPCI + SBP group was significantly higher than that in the PPCI group ( p = 0.036), and the peak value of high-sensitivity troponin T (hsTNT) was lower than that in the PPCI group ( p = 0.048). FIS in the PPCI + SBP group was smaller than that in the PPCI group ( p = 0.047). MS ( p = 0.023) and SI ( p = 0.006) in the PPCI + SBP group were larger than those in the PPCI group. The left ventricular ejection fraction (LVEF) in the PPCI + SBP group was higher than that in the PPCI group ( p = 0.049), and N-terminal pro-B type natriuretic peptide (NT-proBNP) level in the PPCI + SBP group was lower than that in the PPCI group ( p = 0.048). Conclusions: SBP can alleviate I/R injury (MS and SI), decrease myocardial infarction area (peak value of hsTNT and FIS), and improve myocardial reperfusion (MBG and STR) and cardiac function (LVEF and NT-proBNP).
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2021.721011