PCNA, Ki-67, p53, bcl-2 and prognosis in intraoral squamous cell carcinoma of the head and neck

• Published in: Analytical cellular pathology 1997, Vol.14 (2), p.101-110
• Main Authors: Nylander, K, Schildt, E B, Eriksson, M, Roos, G
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Apoptosis; Carcinoma, Squamous Cell - chemistry; Carcinoma, Squamous Cell - diagnosis; Carcinoma, Squamous Cell - mortality; Cell Division; DNA Mutational Analysis; DNA, Neoplasm - analysis; Female; Follow-Up Studies; Head and Neck Neoplasms - chemistry; Head and Neck Neoplasms - diagnosis; Head and Neck Neoplasms - mortality; Humans; Immunohistochemistry; Ki-67 Antigen - analysis; Ki-67 Antigen - genetics; Male; Middle Aged; Other; Polymorphism, Single-Stranded Conformational; Predictive Value of Tests; Prognosis; Proliferating Cell Nuclear Antigen - analysis; Proliferating Cell Nuclear Antigen - genetics; Proto-Oncogene Proteins c-bcl-2 - analysis; Proto-Oncogene Proteins c-bcl-2 - genetics; Survival Analysis; Tumor Suppressor Protein p53 - analysis; Tumor Suppressor Protein p53 - genetics
• ISSN: 0921-8912; 2210-7177; 2210-7185; 1878-3651
• DOI: 10.1155/1997/591251

Eighty patients with primary intraoral squamous cell carcinomas of the head and neck, with a follow-up of 4-14 years were analysed for clinical outcome in relation to immunohistochemical expression of PCNA, Ki-67, p53, bcl-2 and presence of mutations in the p53 gene. The tumor site was not associated with the different parameters calculated. PCNA and Ki-67 labelling showed median values of 56% and 32%, respectively, and neither antigen was of predictive value. Fifty-five percent of the tumours expressed p53, and 38 (48%) had mutations in the p53 gene. No association between the presence of p53 protein or mutations in the p53 gene and clinical outcome was found. Bcl-2 positivity was detected in a minor fraction (10%) of the tumours.