Optimization of extraction and nanoencapsulation of kimchi cabbage by-products to enhance the simulated in vitro digestion of glucosinolates

Kimchi cabbage is a well-known glucosinolate (GLS)-containing vegetable, but its by-products are discarded despite the presence of GLS. The aim of this study was the optimization of the extraction and nanoencapsulation of GLS from kimchi cabbage by-products to enhance the intestinal absorption of GL...

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Bibliographic Details
Published in:Heliyon 2023-06, Vol.9 (6), p.e16525-e16525, Article e16525
Main Authors: Park, Sung Jin, Lee, Min Jung, Choi, Yun-Jeong, Yun, Ye-Rang, Lee, Mi-Ai, Min, Sung Gi, Seo, Hye-Young, Park, Dong Hyeon, Park, Sung Hee
Format: Article
Language:English
Subjects:
absorption
byproducts
cabbage
Chitosan-lipid nanoparticles
digestion
encapsulation
Glucosinolates
intestinal absorption
intestines
kimchi
Kimchi cabbage by-products
methanol
nanocapsules
nanoparticles
Release
Simulated in vitro digestion
ultrasonic treatment
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Summary:Kimchi cabbage is a well-known glucosinolate (GLS)-containing vegetable, but its by-products are discarded despite the presence of GLS. The aim of this study was the optimization of the extraction and nanoencapsulation of GLS from kimchi cabbage by-products to enhance the intestinal absorption of GLS. The optimal GLS extraction conditions included steaming thrice as pretreatment, utilizing 70% methanol, and ultrasonication at 20% amplitude for 15 min. Under these conditions, 80.11 ± 4.40 mg/100 g of GLS extraction was obtained and the extraction yield was 81.70 ± 4.73%. The optimized kimchi cabbage by-product extract (KCE) was coated with chitosan-lipid nanoparticles (KCE-NPs) and their stability and release under simulated in vitro gastrointestinal conditions were evaluated. KCE-NPs protected the encapsulated GLS under acidic gastric conditions and released 91.63 ± 0.76% of GLS in the simulated intestinal medium. Therefore, the proposed KCE-NPs are a promising delivery system for increasing GLS absorption. •Optimization of extraction and nanoencapsulation of GLS was studied.•Kimchi cabbage by-product extract (KCE) was investigated.•Release profile of KCE coated with chitosan-lipid NPs (KCE-NPs) was evaluated.•KCE-NPs protected the encapsulated GLS under acidic gastric conditions.•KCE-NPs released 91.63 ± 0.76% of GLS in simulated intestinal medium.
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2023.e16525