Dietary Nutrients, Proteomes, and Adhesion of Probiotic Lactobacilli to Mucin and Host Epithelial Cells

The key role of diet and environment in human health receives increasing attention. Thus functional foods, probiotics, prebiotics, and synbiotics with beneficial effects on health and ability to prevent diseases are in focus. The efficacy of probiotic bacteria has been connected with their adherence...

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Bibliographic Details
Published in:Microorganisms (Basel) 2018-08, Vol.6 (3), p.90
Main Authors: Celebioglu, Hasan Ufuk, Svensson, Birte
Format: Article
Language:English
Subjects:
Adhesion
Bacteria
Carbohydrates
carbon sources
Correlation analysis
Digestive system
Environmental factors
Epithelial cells
Epithelium
Food
Food selection
Functional foods & nutraceuticals
Gastrointestinal system
Gastrointestinal tract
Immune system
In vitro methods and tests
intestinal cells
Intestine
Lactobacilli
Lactobacillus acidophilus
Mass spectrometry
Microbiota
Microorganisms
moonlighting proteins
Mucin
Nutrients
Polyphenols
Probiotics
protein identification
Proteins
Proteomics
Review
Scientific imaging
surface proteomes
Yogurt
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Summary:The key role of diet and environment in human health receives increasing attention. Thus functional foods, probiotics, prebiotics, and synbiotics with beneficial effects on health and ability to prevent diseases are in focus. The efficacy of probiotic bacteria has been connected with their adherence to the host epithelium and residence in the gut. Several in vitro techniques are available for analyzing bacterial interactions with mucin and intestinal cells, simulating adhesion to the host in vivo. Proteomics has monitored and identified proteins of probiotic bacteria showing differential abundance elicited in vitro by exposure to food components, including potential prebiotics (e.g., certain carbohydrates, and plant polyphenols). While adhesion of probiotic bacteria influenced by various environmental factors relevant to the gastrointestinal tract has been measured previously, this was rarely correlated with changes in the bacterial proteome induced by dietary nutrients. The present mini-review deals with effects of selected emerging prebiotics, food components and ingredients on the adhesion of probiotic lactobacilli to mucin and gut epithelial cells and concomitant abundancy changes of specific bacterial proteins. Applying this in vitro synbiotics-like approach enabled identification of moonlighting and other surface-located proteins of NCFM that are possibly associated with the adhesive mechanism.
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms6030090