Genomic Characterization of Campylobacter jejuni Adapted to the Guinea Pig ( Cavia porcellus ) Host

is the leading bacterial cause of gastroenteritis worldwide with excessive incidence in low-and middle-income countries (LMIC). During a survey for from putative animal hosts in a town in the Peruvian Amazon, we were able to isolate and whole genome sequence two strains from domesticated guinea pigs...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in cellular and infection microbiology 2021-03, Vol.11, p.607747-607747
Main Authors: Parker, Craig T, Cooper, Kerry K, Schiaffino, Francesca, Miller, William G, Huynh, Steven, Gray, Hannah K, Olortegui, Maribel Paredes, Bardales, Paul Garcia, Trigoso, Dixner Rengifo, Penataro-Yori, Pablo, Kosek, Margaret N
Format: Article
Language:English
Subjects:
Campylobacter jejuni
campylobacteriosis
Cellular and Infection Microbiology
gastroenteritis
selenocysteine
source attribution
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:is the leading bacterial cause of gastroenteritis worldwide with excessive incidence in low-and middle-income countries (LMIC). During a survey for from putative animal hosts in a town in the Peruvian Amazon, we were able to isolate and whole genome sequence two strains from domesticated guinea pigs ( ). The isolated from guinea pigs had a novel multilocus sequence type that shared some alleles with other collected from guinea pigs. Average nucleotide identity and phylogenetic analysis with a collection of subsp and subsp suggest that the guinea pig isolates are distinct. Genomic comparisons demonstrated gene gain and loss that could be associated with guinea pig host specialization related to guinea pig diet, anatomy, and physiology including the deletion of genes involved with selenium metabolism, including genes encoding the selenocysteine insertion machinery and selenocysteine-containing proteins.
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2021.607747