Ninety-degree angled collimator: a dosimetric study related to dynamic intensity-modulated radiotherapy in patients with endometrial carcinoma

• Published in: BMC cancer 2023-06, Vol.23 (1), p.515-515, Article 515
• Main Authors: Serarslan, Alparslan, Daştan, Yalçın, Aksu, Telat, Yıldız, Rana Elif, Gürsel, Bilge, Meydan, Deniz, Okumuş, Nilgün Özbek
• Format: Article
• Language: English
• Subjects: Algorithms; Analysis; Bladder; Bone marrow; Cancer; Carcinoma; Care and treatment; Computed tomography; Custom design; Diagnosis; Dosimetry; Drug dosages; Endometrial cancer; Endometrial carcinoma; Endometrium; Femur; Gynecology; Intensity-modulated radiotherapy; Obstetrics; Oncology; Optical instruments; Patient outcomes; Patients; Pelvis; Planning; Radiation dosimetry; Radiation therapy; Radioisotope brachytherapy; Radiotherapy; Rankings; Rectum; Uterine cancer; Vagina; Volumetric modulated arc therapy
• ISSN: 1471-2407; 1471-2407
• DOI: 10.1186/s12885-023-11033-8

Our purpose was to ensure that the dose constraints of the organs at risk (OARs) were not exceeded while increasing the prescription dose to the planning target volume (PTV) from 45 to 50.4 Gray (Gy) with the dynamic intensity-modulated radiotherapy (IMRT) technique. While trying for this purpose, a new dynamic IMRT technique named 90° angled collimated dynamic IMRT (A-IMRT) planning was developed by us. This study was based on the computed tomography data sets of 20 patients with postoperatively diagnosed International Federation of Gynecology and Obstetrics stage 2 endometrial carcinoma. For each patient, conventional dynamic IMRT (C-IMRT, collimator angle of 0° at all gantry angles), A-IMRT (collimator angle of 90° at gantry angles of 110°, 180°, 215°, and 285°), and volumetric modulated arc therapy (VMAT) were planned. Planning techniques were compared with parameters used to evaluate PTV and OARs via dose-volume-histogram analysis using the paired two-tailed Wilcoxon's signed-rank test; p