Frequent Seronegative Primary Hypothyroidism in Myxedema Coma in Japan: Three Case Reports With a Systematic Review

Myxedema coma is a rare life-threatening form of hypothyroidism that manifests as neuropsychiatric, metabolic, respiratory, and cardiovascular dysfunction. From 2010 to 2022, our hospital managed three cases of myxedema coma. While the overall characteristics of these cases were similar to those in...

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Bibliographic Details
Published in:Case reports in endocrinology 2024, Vol.2024 (1), p.2524019
Main Authors: Okuno, Yosuke, Mukai, Kosuke, Tamura, Yuri, Hayakawa, Tomoaki, Fukuhara, Atsunori, Shimomura, Iichiro
Format: Article
Language:English
Subjects:
Antibiotics
Antibodies
Autoantibodies
Autoimmunity
Autopsies
Blood pressure
Cardiac arrhythmia
Case Report
Case reports
Chronic obstructive pulmonary disease
Coma
Consciousness
Heart rate
Hospitals
Hypothyroidism
Kinases
Lymphocytes
Medical colleges
Metabolism
Methicillin
Myxedema
Neutrophils
Patients
Sepsis
Systematic review
Thyroid gland
Thyroid hormones
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Summary:Myxedema coma is a rare life-threatening form of hypothyroidism that manifests as neuropsychiatric, metabolic, respiratory, and cardiovascular dysfunction. From 2010 to 2022, our hospital managed three cases of myxedema coma. While the overall characteristics of these cases were similar to those in previous reports, we noticed that all cases were negative for thyroid autoantibodies and an autopsy in one of the cases exhibited end-stage thyroiditis. During a systematic review of cases from 1999 to 2022, we also noticed that a significant proportion of myxedema coma was caused by seronegative primary hypothyroidism especially in Japan.
ISSN:2090-6501
2090-651X
DOI:10.1155/2024/2524019