IgA Responses Following Recurrent Influenza Virus Vaccination

Influenza is a highly contagious viral respiratory disease that affects millions of people worldwide each year. Annual vaccination is recommended by the World Health Organization to reduce influenza severity and limit transmission through elicitation of antibodies targeting mainly the hemagglutinin...

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Bibliographic Details
Published in:Frontiers in immunology 2020-05, Vol.11, p.902-902
Main Authors: Abreu, Rodrigo B, Clutter, Emily F, Attari, Sara, Sautto, Giuseppe A, Ross, Ted M
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Antibodies, Viral - blood
Antibodies, Viral - immunology
antibody
B-cell
Cohort Studies
Cross Protection
Female
Hemagglutination Inhibition Tests
Humans
IgA
Immunoglobulin A - blood
Immunoglobulin A - immunology
Immunoglobulin G - blood
Immunoglobulin G - immunology
Immunology
influenza
Influenza Vaccines - administration & dosage
Influenza Vaccines - immunology
Influenza, Human - immunology
Influenza, Human - prevention & control
Longitudinal Studies
Male
Vaccination
Vaccines, Inactivated - administration & dosage
Vaccines, Inactivated - immunology
Young Adult
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Summary:Influenza is a highly contagious viral respiratory disease that affects millions of people worldwide each year. Annual vaccination is recommended by the World Health Organization to reduce influenza severity and limit transmission through elicitation of antibodies targeting mainly the hemagglutinin glycoprotein of the influenza virus. Antibodies elicited by current seasonal influenza vaccines are predominantly strain-specific. However, continuous antigenic drift by circulating influenza viruses facilitates escape from pre-existing antibodies requiring frequent reformulation of the seasonal influenza vaccine. Traditionally, immunological responses to influenza vaccination have been largely focused on IgG antibodies, with almost complete disregard of other isotypes. In this report, young adults (18-34 years old) and elderly (65-85 years old) subjects were administered the split inactivated influenza vaccine for 3 consecutive seasons and their serological IgA and IgG responses were profiled. Moreover, correlation analysis showed a positive relationship between vaccine-induced IgA antibody titers and traditional immunological endpoints, exposing vaccine-induced IgA antibodies as an important novel immune correlate during influenza vaccination.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2020.00902