The synthesis, characterization, antioxidant and antimicrobial activity of some novel amides of the esters of substituted 1,4-dihydropyridines

The esters of substituted 1,4-dihydropyirdines (1,4-DHP) are formed in the reaction of an appropriate aldehyde and ethyl acetoacetate in the presence of concentrated water solution of ammonia. The esters form the amides by the reaction with primary amines. The series of the amides has been synthesiz...

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Bibliographic Details
Published in:Journal of the Serbian Chemical Society 2024, Vol.89 (2), p.141-150
Main Authors: Nikolic, Jasmina, Prlainovic, Nevena, Sekularac, Gavrilo, Matovic, Luka, Lazic, Anita, Drmanic, Sasa
Format: Article
Language:English
Subjects:
abts analysis
biologically active compounds
broth microdilution method
dpph analysis
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Summary:The esters of substituted 1,4-dihydropyirdines (1,4-DHP) are formed in the reaction of an appropriate aldehyde and ethyl acetoacetate in the presence of concentrated water solution of ammonia. The esters form the amides by the reaction with primary amines. The series of the amides has been synthesized with the aim to analyze their chemical characteristics, antioxidant and antimicrobial activity. The amine used in this research is 2-aminothiazole. The antioxidant activity is analysed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-Azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) methods and the antimicrobial activity screening was performed by broth microdilution method, using different microbial strains. The characterization of the obtained amides was done by melting points, FTIR, NMR and elemental analysis. The possibilities for further research was suggested, which could lead to the application of selected compounds.
ISSN:0352-5139
1820-7421
DOI:10.2298/JSC231023098N