Spectrophotometric Determination of Losartan Potassium and Hydrochlorothiazide in tablets by Wavelet Transform Approach

A precise, rapid and simple spectrophotometric method development with continuous wavelet transform technique was described in this paper for the simultaneous determination of losartan potassium and hydrochlorothiazide in tablets. The continuous wavelet transform approach based on the application of...

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Bibliographic Details
Published in:Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi 2021-12, Vol.25 (6), p.1432-1437
Main Authors: ÜSTÜNDAĞ, Özgür, DİNÇ, Erdal
Format: Article
Language:English
Subjects:
continuous wavelet transform
hydrochlorothiazide
losartan potassium
quantitative determination
spectrophotometry
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Summary:A precise, rapid and simple spectrophotometric method development with continuous wavelet transform technique was described in this paper for the simultaneous determination of losartan potassium and hydrochlorothiazide in tablets. The continuous wavelet transform approach based on the application of Symlets5-CWT. If the original UV spectra of losartan potassium and hydrochlorothiazide are examined, it is seen that the spectra of these two substances strongly overlap. With the developed Symlets5-CWT method, the analysis was carried out successfully without any pre-separation process. The calibration equations were obtained at 247.7 nm for the losartan potassium determination and at 259.1 nm for the hydrochlorothiazide determination, respectively. The developed methods were tested in terms of validity and applicability.
ISSN:2147-835X
2147-835X
DOI:10.16984/saufenbilder.989654